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Titolo:
SYNTHESIS OF SOME SUBSTITUTED DIBENZODIAZEPINONES AND PYRIDOBENZODIAZEPINONES
Autore:
COHEN VI; JIN BY; COHEN EI; ZEEBERG BR; REBA RC;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,SECT RADIOPHARMACEUT CHEM WASHINGTON DC 20037 UNIV CHICAGO HOSP,DEPT RADIOL,NUCL MED SECT CHICAGO IL 60637
Titolo Testata:
Journal of heterocyclic chemistry
fascicolo: 3, volume: 35, anno: 1998,
pagine: 675 - 686
SICI:
0022-152X(1998)35:3<675:SOSSDA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; CEREBRAL-CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
V.I. Cohen et al., "SYNTHESIS OF SOME SUBSTITUTED DIBENZODIAZEPINONES AND PYRIDOBENZODIAZEPINONES", Journal of heterocyclic chemistry, 35(3), 1998, pp. 675-686

Abstract

Some fluoro- and iodo-derivative of [4-[(4-diisobutylamino)butyl]-1-phenyl]acetyl]-10, 11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one and lkylamino)butyl]-1-phenyl]acetyl]-5,11-dihydro-6H- pyrido[2,3-b][1,4]benzodiazepin-6-ones 6 (Scheme 1)and their analogues were synthesized. The synthesis of dibenzodiazepinones 1 (Scheme 1) is based on the reaction between 1,4-phenylenediamine and substituted benzoic acids. The intermediate pyridobenzodiazepinones 3 (Scheme 1) were prepared by condensation of 2-chloro-3-aminopyridine with methyl anthranilate and its chlorine derivative. The condensation of 4-[(halo)alkyl]phenylacetyl chloride with dibenzodiazepinones and pyridobenzodiazepinones followed by the reaction of mono- or dialkyl- or dialkenylamine provides 6 (Scheme 1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:30:17