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Titolo:
MEDICAL HYPOTHESIS - XENOESTROGENS AS PREVENTABLE CAUSES OF BREAST-CANCER
Autore:
DAVIS DL; BRADLOW HL; WOLFF M; WOODRUFF T; HOEL DG; ANTONCULVER H;
Indirizzi:
DEPT HLTH & HUMAN SERV,OFF ASSISTANT SECRETARY HLTH,200 INDEPENDENCE AVE SW WASHINGTON DC 20201 CORNELL UNIV,MED CTR,STRANG CORNELL CANC RES LAB NEW YORK NY 10021 CUNY,MT SINAI MED CTR,DEPT ENVIRONM & COMMUNITY MED NEW YORK NY 10029 UNIV CALIF SAN FRANCISCO,INST HLTH POLICY RES SAN FRANCISCO CA 94109 MED UNIV S CAROLINA,DEPT BIOMETR & EPIDEMIOL CHARLESTON SC 29425 UNIV CALIF IRVINE,DEPT MED,EPIDEMIOL PROGRAM IRVINE CA 92717
Titolo Testata:
Environmental health perspectives
fascicolo: 5, volume: 101, anno: 1993,
pagine: 372 - 377
SICI:
0091-6765(1993)101:5<372:MH-XAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL BREAST; OVARIAN-CANCER; TUMOR-CELLS; P53 GENE; RISK; MORTALITY; METABOLISM; ESTROGENS; RAT; HEXACHLOROCYCLOHEXANE;
Keywords:
AROMATIC HYDROCARBONS; BREAST CANCER; CHLORINATED ORGANICS; GENETIC SUSCEPTIBILITY; PESTICIDES; XENOBIOTICS; XENOESTROGENS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Davis et al., "MEDICAL HYPOTHESIS - XENOESTROGENS AS PREVENTABLE CAUSES OF BREAST-CANCER", Environmental health perspectives, 101(5), 1993, pp. 372-377

Abstract

Changes in documented risk factors for breast cancer and rates of screening cannot completely explain recent increases in incidence or mortality. Established risk factors for breast cancer, including genetics account for at best 30% of cases. Most of these risk factors can be linked to total lifetime exposure to bioavailable estrogens. Experimental evidence reveals that compounds such as some chlorinated organics, polycyclic aromatic hydrocarbons (PAHs), triazine herbicides, and pharmaceuticals affect estrogen production and metabolism and thus functionas xenoestrogens. Many of these xenoestrogenic compounds also experimentally induce mammary carcinogenesis. Recent epidemiologic studies haw found that breast fat and serum lipids of women with breast cancer contain significantly elevated levels of some chlorinated organics compared with noncancer controls. As the proportion of inherited breast cancer in the population is small, most breast cancers are due to acquired mutations. Thus, the induction of breast cancer in the majority of cases stems from interactions between host factors, including geneticsand environmental carcinogens. We hypothesize that substances such asxenoestrogens increase the risk of breast cancer by mechanisms which include interaction with breast-cancer susceptibility genes. A series of major epidemiologic studies need to be developed to evaluate this hypothesis, including studies of estrogen metabolism, like role of specific xenoestrogenic substances in breast cancer, and relevant genetic-environmental interactions. In addition, experimental studies are needed to evaluate biologic markers of suspect xenoestrogenic and biologicmarkers of host susceptibility and identify pathways of estrogenicitythat affect the development of breast cancer. If xenoestrogens do play a role in breast cancer, reductions in exposure will provide an opportunity for primary prevention of this growing disease. Tests for estrogenicity could become critical screening tools with which to the potential health consequences of new and existing chemicals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:29:43