Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RELATIONSHIPS OF MALARIA MORBIDITY WITH EXPOSURE TO PLASMODIUM-FALCIPARUM IN YOUNG-CHILDREN IN A HIGHLY ENDEMIC AREA
Autore:
SMITH T; CHARLWOOD JD; KITUA AY; MASANJA H; MWANKUSYE S; ALONSO PL; TANNER M;
Indirizzi:
SWISS TROP INST,SOCINSTR 57 CH-4002 BASEL SWITZERLAND IFAKARA CTR IFAKARA TANZANIA HOSP CLIN BARCELONA E-08036 BARCELONA SPAIN
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 2, volume: 59, anno: 1998,
pagine: 252 - 257
SICI:
0002-9637(1998)59:2<252:ROMMWE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATED BED NETS; PERMETHRIN-IMPREGNATED CURTAINS; GAMBIAN CHILDREN; PREVENT MALARIA; WESTERN KENYA; TRANSMISSION; MORTALITY; TRIAL; BEDNETS; INTENSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Smith et al., "RELATIONSHIPS OF MALARIA MORBIDITY WITH EXPOSURE TO PLASMODIUM-FALCIPARUM IN YOUNG-CHILDREN IN A HIGHLY ENDEMIC AREA", The American journal of tropical medicine and hygiene, 59(2), 1998, pp. 252-257

Abstract

To study incidence of clinical Plasmodium falciparum malaria in relation to exposure to parasites, attendance of children less than eighteen months old at a village dispensary in a highly endemic area of Tanzania was recorded. Entomologic inoculation rates (EIRs), estimated as afunction of time period and place of residence, exceeded one sporozoite positive bite per adult per night in some village neighborhoods during the wet season. Incidence of clinical P. falciparum malaria, defined either as fever with parasitemia or as fever with hyperparasitemia,increased with the EIR over the whole range of exposures. Each 10-fold increase in the EIR corresponded to a 1.6-fold increase in incidenceof fever plus parasitemia (95% confidence interval = 1.4-2.0). Therefore reduction of human-vector contacts will probably reduce morbidity incidence even at very high exposures. Incidence showed little relationship to estimated cumulative numbers of inoculations since birth, butdecreased steeply with estimated cu mulative time infected with trophozoites. This suggests that clinical immunity depends mainly on the extent of exposure to blood-stage antigens, not on the diversity of inocula seen, and thus temporary reductions in human-vector contacts are unlikely to result in subsequent increases in morbidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:38:14