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Titolo:
THE ROLE OF INFLUENZA-A VIRUS HEMAGGLUTININ RESIDUE-226 AND RESIDUE-228 IN RECEPTOR SPECIFICITY AND HOST-RANGE RESTRICTION
Autore:
VINES A; WELLS K; MATROSOVICH M; CASTRUCCI MR; ITO T; KAWAOKA Y;
Indirizzi:
UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,2015 LINDEN DR W MADISON WI 53706 UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI MADISON WI 53706 ST JUDE CHILDRENS HOSP,DEPT VIROL & MOL BIOL MEMPHIS TN 38105 IST SUPER SANITA,DEPT VIROL I-00161 ROME ITALY TOTTORI UNIV,FAC AGR,DEPT VET PUBL HLTH TOTTORI 680 JAPAN UNIV TENNESSEE,DEPT PATHOL MEMPHIS TN 38163
Titolo Testata:
Journal of virology
fascicolo: 9, volume: 72, anno: 1998,
pagine: 7626 - 7631
SICI:
0022-538X(1998)72:9<7626:TROIVH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUSES; BINDING SITE; SIALIC-ACID; H3N2; NUCLEOPROTEIN; REPLICATION; EVOLUTION; MUTATIONS; ORIGIN; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Vines et al., "THE ROLE OF INFLUENZA-A VIRUS HEMAGGLUTININ RESIDUE-226 AND RESIDUE-228 IN RECEPTOR SPECIFICITY AND HOST-RANGE RESTRICTION", Journal of virology, 72(9), 1998, pp. 7626-7631

Abstract

Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza virusesdo not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino acids at positions 226 and 228 of hemagglutinin (I-IA) of the H3 subtype are known to be important for this host range restriction, the contributions of specific amino acids at these positions to restriction were not known. Here, me address this issue by generating Has with site-specific mutations of a human virus that contain different amino acid residues at these positions. We also let ducks select replication-competent viruses from a replication-incompetent virus containing a human virus HA by inoculating animals with 10(10.5) 50% egg infectious dose of the latter virus and identifieda mutation in the HA. Our results showed that the Ser-to-Gly mutationat position 228, in addition to the Leu-to Gln mutation at position 226 of the HA of the H3 subtype, is critical for human virus HA to support virus replication in duck intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:09:36