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Titolo:
AMYGDALOID-LESION HYPERPHAGIA - IMPAIRED RESPONSE TO CALORIC CHALLENGES AND ALTERED MACRONUTRIENT SELECTION
Autore:
KING BM; ROSSITER KN; STINES SG; ZAHARAN GM; COOK JT; HUMPHRIES MD; YORK DA;
Indirizzi:
UNIV NEW ORLEANS,DEPT PSYCHOL NEW ORLEANS LA 70148 PENNINGTON BIOMED RES CTR BATON ROUGE LA 70808
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 44, anno: 1998,
pagine: 485 - 493
SICI:
0363-6119(1998)44:2<485:AH-IRT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC OBESITY; PARAVENTRICULAR NUCLEUS; SELF-SELECTION; BODY-WEIGHT; RATS; MORPHINE;
Keywords:
AMYGDALA; CALORIC REGULATION; MACRONUTRIENT SELECTION; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
B.M. King et al., "AMYGDALOID-LESION HYPERPHAGIA - IMPAIRED RESPONSE TO CALORIC CHALLENGES AND ALTERED MACRONUTRIENT SELECTION", American journal of physiology. Regulatory, integrative and comparative physiology, 44(2), 1998, pp. 485-493

Abstract

Lesions of the most posterodorsal aspects of the amygdala in female rats result in hyperphagia and moderate obesity. In the present study, rats with amygdaloid lesions did not increase their daily food intake when their powdered diet was diluted with 25 or 50% nonnutritive bulk. Control animals adjusted their food intake appropriately. In a secondstudy, rats with lesions ate less food (lab chow pellets) than controls when allowed to eat for only 1 h/day for 10 days. In experiment 3, rats were offered a three-choice macronutrient diet. Whereas four of six control animals preferred the high-fat diet, all eight of the rats with amygdaloid lesions displayed a distinct preference for the high-carbohydrate diet, including those that had preferred the high-fat dietbefore surgery. These results, along with the previous finding that identical lesions result in hyperinsulinemia, indicate that the amygdala is involved in both the homeostatic regulation of food (caloric) intake and the selection of macronutrients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:01:54