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Titolo:
FREE FATTY-ACID UPTAKE IN THE MYOCARDIUM AND SKELETAL-MUSCLE USING FLUORINE-18-FLUORO-6-THIA-HEPTADECANOIC ACID
Autore:
MAKI MT; HAAPARANTA M; NUUTILA P; OIKONEN V; LUOTOLAHTI M; ESKOLA O; KNUUTI JM;
Indirizzi:
UNIV TURKU,TURKU PET CTR FIN-20520 TURKU FINLAND UNIV TURKU,DEPT NUCL MED FIN-20520 TURKU FINLAND UNIV TURKU,DEPT MED & CLIN PHYSIOL FIN-20520 TURKU FINLAND UNIV TURKU,RADIOCHEM LAB FIN-20520 TURKU FINLAND
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 8, volume: 39, anno: 1998,
pagine: 1320 - 1327
SICI:
0161-5505(1998)39:8<1320:FFUITM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GLUCOSE-UTILIZATION; LIPID-METABOLISM; INSULIN; REST; QUANTITATION; CARBOHYDRATE; OXIDATION; KINETICS; FOREARM;
Keywords:
FREE FATTY ACIDS; FLUORINE-18-FLUORO-6-THIA-HEPTADECANOIC ACID; MUSCLE; MYOCARDIUM; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Maki et al., "FREE FATTY-ACID UPTAKE IN THE MYOCARDIUM AND SKELETAL-MUSCLE USING FLUORINE-18-FLUORO-6-THIA-HEPTADECANOIC ACID", The Journal of nuclear medicine, 39(8), 1998, pp. 1320-1327

Abstract

14(R,S)-[F-18]fluoro-6-thia-heptadecanoic acid (FTHA) has been recently introduced as a new tracer for fatty acid metabolism. Myocardial [F-18]FTHA uptake is believed to reflect mainly beta-oxidation of the circulating free fatty acids (FFAs), since it is trapped in the mitochondria because subsequent steps of beta-oxidation are inhibited by sulfur heteroatom. We investigated [F-18]FTHA kinetics in myocardial and skeletal muscle in vivo. Methods: Two dynamic PET studies were performedin seven patients with stable coronary artery disease, once in the fasting state and once during euglycemic hyperinsulinemia (serum insulinsimilar to 60 mU/liter). The fractional [F-18] FTHA uptake rates (K-i) were multiplied with serum FFA concentrations and were considered torepresent FFA uptake, Results: Serum FFA concentration decreased by 80% during insulin clamp. After tracer injection, rapid myocardial uptake was identified both in the fasting state and during insulin stimulation. The cardiac image quality was excellent in both occasions. In addition, femoral muscles were clearly visualized in both studies. The fractional myocardial [F-18]FTHA uptake rates (Ki) in the normal myocardial regions were similar in the fasting state (0.11 +/- 0.04 ml/g/min(mean +/- s.d.) and during insulin clamp (0.12 +/- 0.03 ml/g/min; ns). The calculated myocardial FFA uptake was four times higher in the lasting state than during insulin clamp (5.8 +/- 1.7 versus 1.4 +/- 0.5 mu mol/100 g/min, p < 0.005). The femoral muscle fractional [F-18]FTHAuptake rates (K-i) were lower (0.0071 +/- 0.0014 ml/g/min) in the fasting stale than during insulin clamp (0.0127 +/- 0.0036 ml/g/min; p = 0.03), but the estimated femoral muscle FFA uptake was three times higher in the fasting slate (0.38 +/- 0.09 mu mol/100 g/mn) as compared to that during insulin clamp (0.12 +/- 0.05 mu mol/100 g/min, p < 0.005). Conclusion: Fluorine-18-FTHA PET appears to be a feasible method toestimate fatty acid kinetics in myocardial and skeletal muscle. Physiologically reasonable rates of FFA uptake in myocardium and skeletal muscle were obtained. Furthermore the uptake rates were suppressed in response to insulin both in the myocardial and femoral muscle as expected.

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Documento generato il 26/01/20 alle ore 01:10:52