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Titolo:
A MATHEMATICAL-MODEL FOR THE HETEROGENEITY OF MYOCARDIAL PERFUSION USING NITROGEN-13-AMMONIA
Autore:
VISSER KR; MEEDER JG; VANBEEK JHGM; VANDERWALL EE; WILLEMSEN ATM; BLANKSMA PK;
Indirizzi:
UNIV GRONINGEN HOSP,DEPT CARDIOL,POB 30-001 NL-9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,PET CTR NL-9700 RB GRONINGEN NETHERLANDS FREE UNIV AMSTERDAM,INST CARDIOVASC RES,PHYSIOL LAB AMSTERDAM NETHERLANDS UNIV LEIDEN HOSP,DEPT CARDIOL NL-2300 RC LEIDEN NETHERLANDS
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 8, volume: 39, anno: 1998,
pagine: 1312 - 1319
SICI:
0161-5505(1998)39:8<1312:AMFTHO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; NORMAL CORONARY-ARTERIES; BLOOD-FLOW; SYNDROME-X; ANGINA-PECTORIS; N-13 AMMONIA; RESERVE; MECHANISMS; HEART; PAIN;
Keywords:
PERFUSION DISTRIBUTION; LEFT VENTRICLE; FRACTAL DIMENSION; SYNDROME X;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Visser et al., "A MATHEMATICAL-MODEL FOR THE HETEROGENEITY OF MYOCARDIAL PERFUSION USING NITROGEN-13-AMMONIA", The Journal of nuclear medicine, 39(8), 1998, pp. 1312-1319

Abstract

Heterogeneity of left ventricular myocardial perfusion is an important clinical characteristic. Different aspects of this heterogeneity were analyzed. Methods: The coefficient of variation (v), characterizing heterogeneity, was modeled as a function of the number of segments (n), characterizing spatial resolution of the measurement, using two independent pairs of mutually dependent parameters: the first pair describes v as a power function of n, and the second pair adds a correction for n small. n was Varied by joining equal numbers of neighboring segments. Local similarity of the perfusion was characterized by the correlation between the perfusions of neighboring segments, Genesis of the perfusion distribution was modeled by repeated asymmetric subdivision of the perfusion into a volume among two equal subvolumes. These analyses were applied to study the differences between 16 syndrome X patients and 16 age- and sex-matched healthy volunteers using N-13-ammonia parametric PET perfusion data with a spatial resolution of 480 segments. Results: The heterogeneity of patients is higher for the whole range of spatial resolutions considered (2 less than or equal to n less thanor equal to 480; for n = 480, v = 0.22 +/- 0.03 and 0.18 +/- 0.02; p < 0.005). This is because the first pair of parameters differs betweenpatients and volunteers (p < 0.005), whereas the second pair does not(p > 0.1), For both groups of subjects there is a significant positive local correlation for distances up to 30 segments. This correlation is a formal description of the patchy nature of the perfusion distribution. Conclusion: When comparing values of v, these should be based onthe same value of n. The model makes it possible to calculate v for all values of n 480. Mean perfusion together with the two pairs of parameters are necessary and sufficient to describe all aspects of the perfusion distribution. For n small, heterogeneity estimation is less reliable. Patients have a higher heterogeneity because their perfusion distribution is more asymmetrical from the third to the seventh generation of subdivision (8 less than or equal to n less than or equal to 128). Therefore, a spatial resolution of n greater than or equal to 128 is recommended for parametric imaging of perfusion with PET. Patients have only a very slightly more patchy distribution than volunteers. Thedifferences in perfusion between areas with low perfusion and areas with high perfusion is larger in patients.

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Documento generato il 18/01/20 alle ore 13:15:36