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Titolo:
LONG-TERM TREATMENT OF LUPUS NEPHRITIS WITH CYCLOSPORINE-A
Autore:
TAM LS; LI EK; LEUNG CB; WONG KC; LAI FMM; WANG A; SZETO CC; LUI SF;
Indirizzi:
CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT MED & CLIN THERAPEUT SHATIN HONG KONG CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT MED & CLIN THERAPEUT SHATIN HONG KONG CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT ANAT & CELLULAR PATHOL SHATIN HONG KONG
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 8, volume: 91, anno: 1998,
pagine: 573 - 580
SICI:
1460-2725(1998)91:8<573:LTOLNW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHEMATOSUS; THERAPY; CYCLOPHOSPHAMIDE; PREDNISONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Tam et al., "LONG-TERM TREATMENT OF LUPUS NEPHRITIS WITH CYCLOSPORINE-A", QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 91(8), 1998, pp. 573-580

Abstract

We evaluated the efficacy and safety of long-term treatment with cyclosporin A (CSA) in type IV lupus nephritis. Seventeen patients with biopsy-proven WHO type IV lupus nephritis were enrolled in a prospective, open study. Twelve of the 17 completed 48 months of treatment with CSA and prednisolone. Three patients required the addition of azathioprine, at 12, 38 and 47 months, respectively, for cutaneous disease flare with refractory rashes. One patient was lost to follow-up at 40 months. The mean +/- SD duration of treatment was 43.2 +/- 10.1 months (range 15.7-48 months). A significant reduction of proteinuria and a significant rise in serum albumin were noted 1 month after initiation of treatment. Improvement was maintained throughout the study except for three patients who relapsed with recurrence of nephrotic syndrome. There were no significant changes in serum creatinine level or creatinine clearances throughout the study. Repeat renal biopsy at 12 months following treatment with CSA showed histological improvement, with WHO type II changes in all 17 patients accompanying significant reduction in activity indices. Patients with baseline haemoglobin (Hgb) levels <12 g/dl showed significant improvement. Serum C3 and C4 levels were not changed significantly. Corticosteroid-sparing effects were noted. Side-effects included hypertension, gum hypertrophy and mild hirsuitism, but were not serious. Combination therapy using CSA and prednisone is effective and safe for longterm treatment in lupus patients with WHO type IV nephritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:28:54