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Titolo:
EXTRACELLULAR ACIDITY POTENTIATES AMPA RECEPTOR-MEDIATED CORTICAL NEURONAL DEATH
Autore:
MCDONALD JW; BHATTACHARYYA T; SENSI SL; LOBNER D; YING HS; CANZONIERO LMT; CHOI DW;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL,BOX 8111,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,CTR STUDY NERVOUS SYST INJURY ST LOUIS MO 63110
Titolo Testata:
The Journal of neuroscience
fascicolo: 16, volume: 18, anno: 1998,
pagine: 6290 - 6299
SICI:
0270-6474(1998)18:16<6290:EAPARC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-GLUCOSE DEPRIVATION; CEREBELLAR PURKINJE-CELLS; D-ASPARTATE ANTAGONIST; NON-NMDA RECEPTORS; GLUTAMATE RECEPTOR; HIPPOCAMPAL-NEURONS; CEREBRAL-ISCHEMIA; GLOBAL-ISCHEMIA; INTRACELLULAR ACIDOSIS; FOCAL ISCHEMIA;
Keywords:
AMPA; MURINE NEURONAL CULTURE; PH; EXCITOTOXICITY; CYCLOTHIAZIDE; ACIDOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Mcdonald et al., "EXTRACELLULAR ACIDITY POTENTIATES AMPA RECEPTOR-MEDIATED CORTICAL NEURONAL DEATH", The Journal of neuroscience, 18(16), 1998, pp. 6290-6299

Abstract

The extracellular acidity that accompanies brain hypoxia-ischemia is known to reduce both NMDA and AMPA-kainate receptor-mediated currents and NMDA receptor-mediated neurotoxicity. Although a protective effectof acidic pH on AMPA-kainate receptor-mediated excitotoxicity has been assumed, such has not been demonstrated. Paradoxically, we found that lowering extracellular pH selectively increased AMPA-kainate receptor-mediated neurotoxicity in neocortical cell cultures, despite reducing peak elevations in intracellular free Ca2+. This injury potentiationmay, at least in part, be related to a slowed recovery of intracellular Ca2+ homeostasis, observed after AMPA-kainate receptor activation, but not after NMDA receptor activation or exposure to high K+. The ability of acidic pH to selectively augment AMPA-kainate receptor-mediated excitotoxicity may contribute to the prominent role that these receptors play in selective neuronal death after transient global ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:24:20