Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FAVORABLE OUTCOME OF OVARIAN GERM-CELL MALIGNANCIES TREATED WITH CISPLATIN OR CARBOPLATIN-BASED CHEMOTHERAPY - A HELLENIC COOPERATIVE ONCOLOGY GROUP-STUDY
Autore:
DIMOPOULOS MA; PAPADOPOULOU M; ANDREOPOULOU E; PAPADIMITRIOU C; PAVLIDIS N; ARAVANTINOS G; ASPROPOTAMITIS A; ANAGNOSTOPOULOS A; FOUNTZILAS G; MICHALAS S; PECTACIDES D;
Indirizzi:
UNIV ATHENS,SCH MED,DEPT CLIN THERAPEUT ATHENS 11528 GREECE UNIV ATHENS,SCH MED,DEPT GYNECOL ATHENS 11528 GREECE METAXA CANC HOSP,DEPT MED ONCOL BOTASSI 18537 PIRAEUS GREECE UNIV IOANNINA,DEPT MED ONCOL GR-45110 IOANNINA GREECE AGII ANARGIRI CANC HOSP,DEPT MED ONCOL ATHENS 14564 GREECE ARISTOTELIAN UNIV THESSALONIKI,DEPT MED GR-54006 THESSALONIKI GREECE
Titolo Testata:
Gynecologic oncology (Print)
fascicolo: 1, volume: 70, anno: 1998,
pagine: 70 - 74
SICI:
0090-8258(1998)70:1<70:FOOOGM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND-LOOK LAPAROTOMY; TUMORS; BLEOMYCIN; VINBLASTINE; EXPERIENCE; ETOPOSIDE; TRIAL; CYCLOPHOSPHAMIDE; DYSGERMINOMA; DACTINOMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Dimopoulos et al., "FAVORABLE OUTCOME OF OVARIAN GERM-CELL MALIGNANCIES TREATED WITH CISPLATIN OR CARBOPLATIN-BASED CHEMOTHERAPY - A HELLENIC COOPERATIVE ONCOLOGY GROUP-STUDY", Gynecologic oncology (Print), 70(1), 1998, pp. 70-74

Abstract

Purpose. To evaluate the outcome and the prognosis of patients with ovarian germ cell malignancies who were treated with platinum-based chemotherapy immediately after initial surgery. Methods. We conducted a retrospective review of patients with ovarian germ cell tumors who werereferred for consideration of treatment to the Departments of MedicalOncology participating in the Hellenic Cooperative Oncology Group. Results. Over a 10-year period 53 patients were included in our study. There were 13 patients with dysgerminoma and 40 patients with nondysgerminomatous tumors. Forty percent of patients underwent complete resection of their tumors. Platinum-based chemotherapy consisted primarily of cisplatin, vinblastine, and bleomycin (PVB) in 9 patients; bleomycin, etoposide, and cisplatin (BEP) in 15 patients; and bleomycin, etoposide, and carboplatin (BEC) in 25 patients. With a median follow-up of 39 months, 5 patients developed progressive disease and died of their tumor and 1 patient died of bleomycin-induced lung toxicity with no evidence of active tumor. The 5-year overall survival was 100% for patients with dysgerminoma and 85% for patients with nondysgerminomatous tumors. Eighty percent of patients with advanced nondysgerminomatous tumors and residual disease after surgery remain disease free. Conclusion. With this study we confirm that patients with ovarian germ cell malignancies have a favorable outcome when treated with platinum-based chemotherapy. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:16:19