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Titolo:
ASSESSMENT OF CENTRAL-NERVOUS-SYSTEM INVOLVEMENT IN GAMBIENSE TRYPANOSOMIASIS - VALUE OF THE CEREBROSPINAL WHITE CELL COUNT
Autore:
MIEZAN TW; MEDA HA; DOUA F; YAPO FB; BALTZ T;
Indirizzi:
OCCGE,CTR MURAZ 01,BP 153 BOBO DIOULASSO BURKINA FASO PROJET RECH CLIN TRYPANOSOMIASE DALOA COTE IVOIRE OCCGE,INST PIERRE RICHET BOUAKE COTE IVOIRE CTR HOSP UNIV COCODY ABIDJAN COTE IVOIRE UNIV BORDEAUX 2,LAB IMMUNOL & PARASITOL MOL F-33076 BORDEAUX FRANCE
Titolo Testata:
TM & IH. Tropical medicine & international health
fascicolo: 7, volume: 3, anno: 1998,
pagine: 571 - 575
SICI:
1360-2276(1998)3:7<571:AOCIIG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRUCEI;
Keywords:
TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS; CENTRAL NERVOUS SYSTEM INVOLVEMENT; IN VITRO CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
T.W. Miezan et al., "ASSESSMENT OF CENTRAL-NERVOUS-SYSTEM INVOLVEMENT IN GAMBIENSE TRYPANOSOMIASIS - VALUE OF THE CEREBROSPINAL WHITE CELL COUNT", TM & IH. Tropical medicine & international health, 3(7), 1998, pp. 571-575

Abstract

OBJECTIVE To assess, in a clinical setting, the comparative values ofconventional criteria used in the diagnosis of central nervous system(CNS) involvement in Trypanosoma brucei gambiense sleeping sickness: white cell count (WCC) in cerebrospinal fluid (CSF) > 5 x 10(6) cells/l; total protein concentration in CSF > 10 mg/100 ml); evidence of trypanosomes in CSF following double centrifugation (DC). METHOD In vitroculture of CSF was used as the gold standard. RESULTS The study showed that WCC is,by itself, as sensitive for the diagnosis of the CNS involvement as the usually recommended combination of three conventional criteria. The specificity of WCC is improved while the sensitivity is reduced when the cut-off point is set at a higher value (WCC > 10 x 10(6)/l). CONCLUSION In poorly equiped laboratories, the diagnosis of CNS involvement in patients with confirmed systemic infection should be based only on the WCC. However, a pilot study is needed to assess the feasibility and reliability of the WCC handled by 'front line' personnel, for different cut-off values.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:08:03