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Titolo:
ADAPTATION OF THE HUMAN PANCREAS TO INHIBITION OF LUMINAL PROTEOLYTICACTIVITY
Autore:
FRIESS H; KLEEFF J; ISENMANN R; MALFERTHEINER P; BUCHLER MW;
Indirizzi:
UNIV BERN,INSELSPITAL,DEPT VISCERAL & TRANSPLANTAT SURG CH-3010 BERN SWITZERLAND UNIV BERN,DEPT VISCERAL & TRANSPLANTAT SURG CH-3010 BERN SWITZERLAND UNIV ULM,DEPT SURG & GASTROENTEROL ULM GERMANY OTTO VON GUERICKE UNIV,DEPT GASTROENTEROL HEPATOL & INFECT DIS MAGDEBURG GERMANY
Titolo Testata:
Gastroenterology
fascicolo: 2, volume: 115, anno: 1998,
pagine: 388 - 396
SICI:
0016-5085(1998)115:2<388:AOTHPT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-SECRETION; TRYPSIN-INHIBITOR; PLASMA CHOLECYSTOKININ; FEEDBACK-REGULATION; EXOCRINE PANCREAS; PROTEINASE-INHIBITOR; SOMATOSTATIN ANALOG; GASTRIC FUNCTION; RAT PANCREAS; CAMOSTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
H. Friess et al., "ADAPTATION OF THE HUMAN PANCREAS TO INHIBITION OF LUMINAL PROTEOLYTICACTIVITY", Gastroenterology, 115(2), 1998, pp. 388-396

Abstract

Background & Aims: Feedback regulation of pancreatic enzyme secretionis well established in animals, and their pancreases are able to adapt to intraduodenal inhibition of pancreatic enzymes by proteinase inhibitors such as Camostate (FOY-305; Schwarz GmbH, Monheim, Germany). Inthis study, we addressed whether similar adaptive changes occur in the human pancreas after 4 weeks of 2 g/day Camostate application. Methods: Before, at the end of, and 2 weeks after 4-week Camostate treatment (four times 500 mg daily), pancreatic changes were analyzed with theuse of a secretin-cerulein test, a test-meal stimulation, cholecystokinin plasma measurement, and standardized ultrasonographic investigations of the pancreas. Results: Duodenal trypsin output after secretion stimulation was significantly increased (+44%; P < 0.01) and duodenal bicarbonate output decreased 22% (P < 0.05) after 4 weeks of Camostateapplication. The size of the pancreatic head (vertical) increased 8% (P < 0.05) at week 4 and decreased to pretreatment values 2 weeks after treatment (week 6). The other three diameters measured (head oblique, body, and tail) showed a similar pattern. Stimulated cholecystokininplasma levels 15 minutes after application of a standard test meal increased 62% (P < 0.05). Conclusions: The human pancreas adapts to oralapplication of the proteinase inhibitor Camostate. These findings support the theory that feedback control of the exocrine pancreas operates in humans.

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Documento generato il 10/07/20 alle ore 02:58:21