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Titolo:
CYCLOOXYGENASE-2 IS INDUCED IN COLONIC EPITHELIAL-CELLS IN INFLAMMATORY BOWEL-DISEASE
Autore:
SINGER II; KAWKA DW; SCHLOEMANN S; TESSNER T; RIEHL T; STENSON WF;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT MED,CAMPUS BOX 8124 ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MED ST LOUIS MO 63110 MERCK RES LABS,DEPT INFLAMMAT RES RAHWAY NJ 00000
Titolo Testata:
Gastroenterology
fascicolo: 2, volume: 115, anno: 1998,
pagine: 297 - 306
SICI:
0016-5085(1998)115:2<297:CIIICE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN G/H SYNTHASE-1; INTERLEUKIN-1 ACTIVITY; ULCERATIVE-COLITIS; GENE-EXPRESSION; RAT; LEUKOTRIENE-B4; PROLIFERATION; LOCALIZATION; INHIBITION; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
I.I. Singer et al., "CYCLOOXYGENASE-2 IS INDUCED IN COLONIC EPITHELIAL-CELLS IN INFLAMMATORY BOWEL-DISEASE", Gastroenterology, 115(2), 1998, pp. 297-306

Abstract

Background & Aims: Prostaglandins are synthesized by cyclooxygenases (COX)-1 and -2. The expression and cellular localization of COX-1 and COX-2 in normal human colon and inflammatory bowel disease (IBD) surgical resections were studied. Methods: COX-1 and COX-2 protein expression and cellular localization were assessed by Western blotting and immunohistochemistry. Results: COX-1 protein was expressed at equal levels in normal, Crohn's disease, and ulcerative colitis colonic epithelial cells. COX-2 protein was not detected in normal epithelial cells butwas detected in Crohn's disease and ulcerative colitis epithelial cells. Immunohistochemistry of normal, Crohn's colitis, and ulcerative colitis tissue showed equivalent COX-1 expression in epithelial cells inthe lower half of the colonic crypts. COX-2 expression was absent from normal colon, whereas in Crohn's colitis and ulcerative colitis, COX-2 was observed in apical epithelial cells and in lamina propria mononuclear cells. In Crohn's ileitis, COX-2 was present in the villus epithelial cells. In ulcerative colitis, colonic epithelial cells expressing COX-2 also expressed inducible nitric oxide synthase. Conclusions: COX-1 was localized in the crypt epithelium of the normal ileum and colon, and its expression was unchanged in IBD. COX-2 was undetectable in normal ileum or colon, but it was induced in apical epithelial cellsof inflamed foci in IBD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:18:34