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Titolo:
SYNTHESIS OF 1,2-DIACYL-3-NICOTINOYL GLYCEROL DERIVATIVES AND EVALUATION OF THEIR ACUTE EFFECTS ON PLASMA-LIPIDS IN THE RAT
Autore:
CORDI A; LACOSTE JM; DUHAULT J; ESPINAL J; BOULANGER M; BROUX O; HUSSON B; VOLLAND JP; MAHIEU JP;
Indirizzi:
INST RECH SERVIER,DIV MED CHEM,11 RUE MOULINEAUX F-92150 SURESNES FRANCE INST RECH SERVIER,DIV METAB DIS F-92150 SURESNES FRANCE INST RECH SERVIER,DIV ANALYT CHEM F-92150 SURESNES FRANCE
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 9, volume: 45-2, anno: 1995,
pagine: 997 - 1001
SICI:
0004-4172(1995)45-2:9<997:SO1GDA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC-ACID; NIACIN;
Keywords:
ATHEROSCLEROSIS; CAS 59-67-6; CAS 160555-46-4; (D,L)-1,2-DIPALMITOYL-3-NICOTINOYL GLYCEROL; LIPID LOWERING AGENT; NICOTINIC ACID, DERIVATIVES; S 16961;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Cordi et al., "SYNTHESIS OF 1,2-DIACYL-3-NICOTINOYL GLYCEROL DERIVATIVES AND EVALUATION OF THEIR ACUTE EFFECTS ON PLASMA-LIPIDS IN THE RAT", Arzneimittel-Forschung, 45-2(9), 1995, pp. 997-1001

Abstract

Nicotinic acid (CAS 59-67-6) is the only hypolipidemic agent whose activity has been shown both on atherosclerotic lesions and on long termmortality Unfortunately, its use is hindered by the frequent occurrence (> 70 %) of adverse reactions (i.e. cutaneous rash, pruritus and most significantly, flush). New prodrugs of nicotinic acid have been prepared by the use of diacylglycerol esters In the rat, after acute oraladministration of these products, a significant decrease of the free fatty acid plasma levels was obtained without the dramatic ina ease innicotinic acid plasma levels observed after the oral administration of an equimolecular dose of nicotinic acid. The most interesting ester,S 16961 ((d, l)-1,2-dipalmitoyl-3-nicotinoyl glycerol, CAS 160555-46-4) is undergoing clincial trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:39:05