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Titolo:
EX-VIVO ANTIPLATETLET EFFECTS OF ISOCARBACYCLIN METHYL-ESTER INCORPORATED IN LIPID MICROSPHERES IN RABBITS
Autore:
INOUE K; AOKI Y; HAYASHI M; KITAHARA S; TANABE H; KIYOKI M; ARAKI H;
Indirizzi:
TEIJIN LTD,TEIJIN INST BIOMED RES,PHARMACEUT DEV RES LABS,PHARMACOL RES DEPT,4-3-2 ASAHIGAOKA HINO TOKYO 191 JAPAN TAISHO PHARMACEUT CO LTD,RES CTR,DEPT PHARMACOL 2 OMIYA SAITAMA JAPAN
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 9, volume: 45-2, anno: 1995,
pagine: 980 - 984
SICI:
0004-4172(1995)45-2:9<980:EAEOIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
STABLE PROSTACYCLIN ANALOG; EXPERIMENTAL-ANIMALS; PROSTAGLANDIN-I2 ANALOG; AGGREGATION; STABILITY; ARTERIES; OP-41483; PGI2;
Keywords:
CAS 88931-51-5; ISOCARBACYCLIN METHYL ESTER, IN LIPID MICROSPHERES; PLATELET AGGREGATION; TEI-9090; TTC-909, PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Inoue et al., "EX-VIVO ANTIPLATETLET EFFECTS OF ISOCARBACYCLIN METHYL-ESTER INCORPORATED IN LIPID MICROSPHERES IN RABBITS", Arzneimittel-Forschung, 45-2(9), 1995, pp. 980-984

Abstract

Effect of TTC-909, a chemically stable isocarbucyclin methyl ester (CAS 88931-51-5, TEI-9090) incorporated in lipid microspheres, on platelet aggregation was tested in conscious rabbits TTC-909 significantly inhibited platelet aggregation induced ADP at early times after bolus i.v. injection from the dose of 0.3 mu g/kg in a dose-dependent manner. Similarly, TTC-909 significantly inhibited platelet aggregation induced by ADP during the venous infusion from the dose of 100 ng/kg/min, also in a dose-dependent manner. The anti-platelet effect of TTC-909 was observed at a close lower than that inducing hypotensive effect whengiven as both bolus i.v. and venous infusion. On the other hand prostaglandin (PG)E(1) (LM) - PGE(1) incorporated in lipid microspheres - reduced blood pressure without having art anti-platelet effect. These results indicate that TTC-909 may be a potent anti-thrombotic drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:43:45