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Titolo:
ANTIGEN-RECEPTOR JUNCTIONAL DIVERSITY IN GROWTH-FACTOR-RECEPTOR MUTANT MICE
Autore:
RODEWALD HR; HALLER C;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND
Titolo Testata:
Developmental and comparative immunology
fascicolo: 3, volume: 22, anno: 1998,
pagine: 351 - 365
SICI:
0145-305X(1998)22:3<351:AJDIGM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; PRE-B-CELLS; HEMATOPOIETIC STEM-CELLS; FC-GAMMA-RII/III; BETA-CHAIN GENE; C-KIT; INTERLEUKIN-7 RECEPTOR; LYMPHOID DEVELOPMENT; LINEAGE COMMITMENT; PROGENITOR CELLS;
Keywords:
CYTOKINES; GROWTH/DIFFERENTIATION FACTOR RECEPTORS; RECEPTOR-TYROSINE-KINASE; C-KIT; COMMON CYTOKINE RECEPTOR GAMMA CHAIN (GAMMA(C)); JAK-STAT SIGNALING PATHWAYS; B CELL AND T CELL RECEPTOR REPERTOIRE; D(J) AND V(D)J REARRANGEMENTS; V-H GENE USAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald e C. Haller, "ANTIGEN-RECEPTOR JUNCTIONAL DIVERSITY IN GROWTH-FACTOR-RECEPTOR MUTANT MICE", Developmental and comparative immunology, 22(3), 1998, pp. 351-365

Abstract

Precursor lymphocytes undergo expansion prior to immunoglobulin (Ig) or T cell receptor (TCR) rearrangements. Development of thymocytes, but not B cells, is entirely blocked in mice lacking both the receptor-tyrosine-kinase c-kit and the common cytokine receptor gamma chain (gamma(c)). In c-kit(-)gamma c(-)mice, TCR beta rearrangements are limitedto mono- or oligoclonal DJ junctions. Here, effects of lack of c-kit or gamma(c), or both, on the junctional diversity of TCR gamma and delta, and Ig V-H(D-H)J(H) loci were analyzed. All rearrangements were present in wildtype and mutant mice. However, sequencing of the junctions revealed monoclonal TCR gamma (V(gamma 2)J(gamma 1)) and TCR delta (V-delta 1(D-delta)J(delta 2)) joints in c-kit(-)gamma(c)(-), but not c-kit(+)gamma(c)(-) or wildtype thymocytes. In contrast to TCR beta, gamma and delta loci, V(H)D(H)J(H) junctions were more diverse in c-kit(-)gamma(c)(-)mice. Thus, the two analyzed growth factor receptors mediate signaling pathways required for progenitor expansion and generation of junctional diversity at TCR loci, but have less influence on the diversity of IgH junctions. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:39:30