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Titolo:
MOLECULAR-DETECTION AND QUANTITATION OF THE CHEMOKINE RANTES MESSENGER-RNA IN NEUROLOGICAL BRAIN
Autore:
HVAS J; BERNARD CCA;
Indirizzi:
AARHUS UNIV,DEPT MED MICROBIOL & IMMUNOL,BARTHOLIN BLD DK-8000 AARHUSC DENMARK LA TROBE UNIV,NEUROIMMUNOL LAB BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 6, volume: 106, anno: 1998,
pagine: 598 - 604
SICI:
0903-4641(1998)106:6<598:MAQOTC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; GENE; RNA;
Keywords:
CYTOKINES; CHEMOKINES; RANTES; T-CELLS; MS; NEUROLOGICAL DISORDERS; PCR; QUANTITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J. Hvas e C.C.A. Bernard, "MOLECULAR-DETECTION AND QUANTITATION OF THE CHEMOKINE RANTES MESSENGER-RNA IN NEUROLOGICAL BRAIN", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 106(6), 1998, pp. 598-604

Abstract

Accumulation of T-cells in the brains of patients with neurological disorders prompted a molecular analysis of brain tissue for expression of the chemokine RANTES, which is known to be a T-cell activator and chemoattractant. A fast, sensitive and reproducible technique was developed, based on the polymerase chain reaction and nonradioactive detection. The method could detect and quantitate RANTES in small amounts ofbrain tissue from all patients with multiple sclerosis, and in some patients with other neural or inflammatory diseases. The data indicate constitutive expression of RANTES in brain from some neurological disorders where its downregulation can have therapeutic benefits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:04:39