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Titolo:
INCREASED RESTING CA2+ MAINTAINS THE MYOGENIC TONE AND ACTIVATES K+ CHANNELS IN ARTERIES FROM YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
ASANO M; MATSUDA T; HAYAKAWA M; ITO KM; ITO K;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PHARMACOL,MIZUHO KU NAGOYA AICHI 467 JAPAN MIYAZAKI UNIV,FAC AGR,DEPT VET PHARMACOL MIYAZAKI 88921 JAPAN
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 3, volume: 247, anno: 1993,
pagine: 295 - 304
SICI:
0922-4106(1993)247:3<295:IRCMTM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; CYTOSOLIC FREE CALCIUM; POTASSIUM CHANNELS; CEREBRAL-ARTERIES; FEMORAL ARTERIES; MEMBRANE; CELLS; NOREPINEPHRINE; SENSITIVITY; BINDING;
Keywords:
VOLTAGE-DEPENDENT CA2+ CHANNELS; TRANSMEMBRANE CA2+ INFLUX; ARTERIAL MYOGENIC TONE; CA2+-ACTIVATED K+ CHANNELS; SPONTANEOUSLY HYPERTENSIVE RATS (SHR); (EARLY HYPERTENSIVE STAGES);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Asano et al., "INCREASED RESTING CA2+ MAINTAINS THE MYOGENIC TONE AND ACTIVATES K+ CHANNELS IN ARTERIES FROM YOUNG SPONTANEOUSLY HYPERTENSIVE RATS", European journal of pharmacology. Molecular pharmacology section, 247(3), 1993, pp. 295-304

Abstract

We examined whether the Ca2+ channel function in the resting state alters the resting tone in femoral and carotid arteries from spontaneously hypertensive rats (SHR) at early hypertensive stages (6 and 4 weeksof age), and data were compared with findings in age-matched normotensive Wistar-Kyoto rats (WKY). Strips of femoral and carotid arteries from 6-week-old SHR, but not from WKY, maintained a myogenic tone, thatis, the resting tone decreased when 10(-7) M nifedipine was added. A similar myogenic tone was maintained in 4-week-old SHR. In strips of carotid arteries preloaded with fura-2, a fluorescent Ca2+ indicator, the decrease in cytoplasmic Ca2+ concentration following 0-Ca2+ solution or 5 x 10(-7) M nicardipine was significantly greater in SHR than inWKY. The basal Ca-45 influx in femoral and carotid arteries from 6-week-old SHR was significantly increased when compared with WKY, and this increase in SHR was abolished by 10(-7) M nifedipine. The addition of charybdotoxin (a blocker of large conductance Ca2+-activated K+ channels) or of Bay k 8644 (an agonist of L-type voltage-dependent Ca2+ channels; VDCs), caused a concentration-dependent contraction, which wassignificantly greater in 6- and 4-week-old SHR than in WKY. These results suggest that the Ca2+ influx via L-type VDCs was increased in theresting state of femoral and carotid arteries from SHR at the early hypertensive stages, and therefore the myogenic tone was maintained andcharybdotoxin-sensitive K+ channels were highly activated.

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Documento generato il 25/11/20 alle ore 18:35:31