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Titolo: INCREASED RESTING CA2+ MAINTAINS THE MYOGENIC TONE AND ACTIVATES K+ CHANNELS IN ARTERIES FROM YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
Autore: ASANO M; MATSUDA T; HAYAKAWA M; ITO KM; ITO K;
- Indirizzi:
- NAGOYA CITY UNIV,SCH MED,DEPT PHARMACOL,MIZUHO KU NAGOYA AICHI 467 JAPAN MIYAZAKI UNIV,FAC AGR,DEPT VET PHARMACOL MIYAZAKI 88921 JAPAN
- Titolo Testata:
- European journal of pharmacology. Molecular pharmacology section
fascicolo: 3,
volume: 247,
anno: 1993,
pagine: 295 - 304
- SICI:
- 0922-4106(1993)247:3<295:IRCMTM>2.0.ZU;2-N
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- VASCULAR SMOOTH-MUSCLE; CYTOSOLIC FREE CALCIUM; POTASSIUM CHANNELS; CEREBRAL-ARTERIES; FEMORAL ARTERIES; MEMBRANE; CELLS; NOREPINEPHRINE; SENSITIVITY; BINDING;
- Keywords:
- VOLTAGE-DEPENDENT CA2+ CHANNELS; TRANSMEMBRANE CA2+ INFLUX; ARTERIAL MYOGENIC TONE; CA2+-ACTIVATED K+ CHANNELS; SPONTANEOUSLY HYPERTENSIVE RATS (SHR); (EARLY HYPERTENSIVE STAGES);
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 33
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- M. Asano et al., "INCREASED RESTING CA2+ MAINTAINS THE MYOGENIC TONE AND ACTIVATES K+ CHANNELS IN ARTERIES FROM YOUNG SPONTANEOUSLY HYPERTENSIVE RATS", European journal of pharmacology. Molecular pharmacology section, 247(3), 1993, pp. 295-304
Abstract
We examined whether the Ca2+ channel function in the resting state alters the resting tone in femoral and carotid arteries from spontaneously hypertensive rats (SHR) at early hypertensive stages (6 and 4 weeksof age), and data were compared with findings in age-matched normotensive Wistar-Kyoto rats (WKY). Strips of femoral and carotid arteries from 6-week-old SHR, but not from WKY, maintained a myogenic tone, thatis, the resting tone decreased when 10(-7) M nifedipine was added. A similar myogenic tone was maintained in 4-week-old SHR. In strips of carotid arteries preloaded with fura-2, a fluorescent Ca2+ indicator, the decrease in cytoplasmic Ca2+ concentration following 0-Ca2+ solution or 5 x 10(-7) M nicardipine was significantly greater in SHR than inWKY. The basal Ca-45 influx in femoral and carotid arteries from 6-week-old SHR was significantly increased when compared with WKY, and this increase in SHR was abolished by 10(-7) M nifedipine. The addition of charybdotoxin (a blocker of large conductance Ca2+-activated K+ channels) or of Bay k 8644 (an agonist of L-type voltage-dependent Ca2+ channels; VDCs), caused a concentration-dependent contraction, which wassignificantly greater in 6- and 4-week-old SHR than in WKY. These results suggest that the Ca2+ influx via L-type VDCs was increased in theresting state of femoral and carotid arteries from SHR at the early hypertensive stages, and therefore the myogenic tone was maintained andcharybdotoxin-sensitive K+ channels were highly activated.
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Documento generato il 25/11/20 alle ore 18:35:31