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Titolo:
BLUNTED SERUM ERYTHROPOIETIN RESPONSE TO ANEMIA IN PATIENTS POLYTRANSFUSED FOR BETA-THALASSEMIA MAJOR
Autore:
CHEN JS; LIN KH; WANG ST; TSAO CJ; YEH TF;
Indirizzi:
NATL CHENG KUNG UNIV HOSP,DEPT PEDIAT,138 SHENG LI RD TAINAN 704 TAIWAN NATL CHENG KUNG UNIV HOSP,DEPT PUBL HLTH TAINAN 704 TAIWAN NATL CHENG KUNG UNIV HOSP,DEPT INTERNAL MED TAINAN 704 TAIWAN NATL TAIWAN UNIV HOSP,DEPT PEDIAT TAIPEI 10016 TAIWAN
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 2, volume: 20, anno: 1998,
pagine: 140 - 144
SICI:
1077-4114(1998)20:2<140:BSERTA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE ERYTHROPOIETIN; PROGENITOR CELLS; APLASTIC-ANEMIA; IRON-DEFICIENCY; CHILDREN; OXYGEN; DISEASE; SICKLE; TITERS; LIVER;
Keywords:
ERYTHROPOIETIN; BETA-THALASSEMIA MAJOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Chen et al., "BLUNTED SERUM ERYTHROPOIETIN RESPONSE TO ANEMIA IN PATIENTS POLYTRANSFUSED FOR BETA-THALASSEMIA MAJOR", Journal of pediatric hematology/oncology, 20(2), 1998, pp. 140-144

Abstract

Purpose: To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for beta-thalassemia major. Patients and Methods: We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients polytransfused for beta-thalassemia major, in 18 patients with iron deficiency anemia (IDA), and 32 healthy subjects. Serum EPO levels were assayed by an enzyme immunoassay. Results: in both groups with beta-thalassemia major and IDA, serum EPO levels were significantly elevated (114 +/- 71 and 239 +/- 217 mU/mL, respectively). There was a significant inverse correlation between log EPO values and Hb concentrations in patients with beta-thalassemia major (r = 0.61; p <0.01) and IDA (r = 0.81; p <0.01). In a semilogarithmic plot, the slope of the regression line obtained in patients withbeta-thalassemia major was significantly lower than that of LDA (p <0.01), suggesting a blunted EPO response to anemia in patients polytransfused for beta-thalassemia major. The elevation of serum EPO in patients with beta-thalassemia major was poorly related to clinical Variables except serum ferritin. Conclusions: We conclude that a significant inverse relationship between serum EPO levels and Hb concentration exists in patients with beta-thalassemia major. However, this EPO response in patients with anemia caused by beta-thalassemia major may be blunted when compared to patients with IDA.

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Documento generato il 11/07/20 alle ore 11:21:47