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Titolo:
REGIONAL PATTERN OF RETINOID-X RECEPTOR-ALPHA GENE-EXPRESSION IN THE CENTRAL-NERVOUS-SYSTEM OF THE CHICKEN-EMBRYO AND ITS UP-REGULATION BY EXPOSURE TO 9-CIS RETINOIC ACID
Autore:
HOOVER F; GLOVER JC;
Indirizzi:
UNIV OSLO,INST BASIC MED SCI,DEPT ANAT,PB 1105 BLINDERN N-0317 OSLO NORWAY UNIV OSLO,INST BASIC MED SCI,DEPT ANAT N-0317 OSLO NORWAY
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 398, anno: 1998,
pagine: 575 - 586
SICI:
0021-9967(1998)398:4<575:RPORRG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
9-CIS-RETINOIC ACID; BINDING-PROTEINS; SPINAL-CORD; DIFFERENTIAL PATTERN; GAMMA TRANSCRIPTS; BETA TRANSCRIPTS; MOUSE EMBRYOS; NEURAL-CREST; EARLY MARKER; RXR GENES;
Keywords:
RETINOID RECEPTOR; VITAMIN-A; SEGMENTATION; RHOMBOMERE; NEURAL TUBE; PATTERN FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
F. Hoover e J.C. Glover, "REGIONAL PATTERN OF RETINOID-X RECEPTOR-ALPHA GENE-EXPRESSION IN THE CENTRAL-NERVOUS-SYSTEM OF THE CHICKEN-EMBRYO AND ITS UP-REGULATION BY EXPOSURE TO 9-CIS RETINOIC ACID", Journal of comparative neurology, 398(4), 1998, pp. 575-586

Abstract

We have investigated the expression of the retinoid X receptor-alpha (RXR alpha) gene in the developing chicken embryo by using nonradioactive wholemount in situ hybridization. At the earliest stage of development examined (stage 9; Hamburger and Hamilton [1951] J. Morphol. 88:49-92), we detect RXR alpha transcripts in a stretch of neuroepitheliumcorresponding roughly to the presumptive caudal hindbrain. Upon formation of the rhombomeres at stage 12, a strongly RXR alpha-positive region extends from a sharp rostral limit at the boundary between rhombomeres 6 and 7 caudad to at least the level of somite 9. This pattern ofhighest expression continues at least until stage 22 but with some variability in the caudal extent. A lower level of expression extends throughout the spinal cord. Transverse sections show that RXR alpha transcripts are expressed in a gradient, with the highest levels near the roof plate and decreasing toward the floor plate. At later stages, thelevel of expression is highest in the proliferative ventricular zone. However, at reduced levels, RXR alpha transcripts are also detectablein the mantle zone as well as outside the developing central nervous system, for example, in the neural crest and the limb buds. Nine-cis-retinoic acid up-regulates RXR alpha transcripts at stages 19.5-22.0 within a few hours, augmenting but not expanding the expression pattern. Northern blots demonstrate the potential expression of multiple RXR alpha isoforms in the central nervous system at posthatch stages. Theseresults implicate the RXR alpha receptor in both rostrocaudal and transverse patterning of the neural tube. J. Comp. Neurol. 398:575-586, 1998. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 07/07/20 alle ore 22:32:09