Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHARACTERISTIC PROLIFERATIONS OF RETICULAR AND DENDRITIC CELLS IN ANGIOIMMUNOBLASTIC LYMPHOMA
Autore:
JONES D; JORGENSEN JL; SHAHSAFAEI A; DORFMAN DM;
Indirizzi:
BRIGHAM & WOMENS HOSP,DEPT PATHOL,75 FRANCIS ST BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT PATHOL BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DIV HEMATOPATHOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115
Titolo Testata:
The American journal of surgical pathology
fascicolo: 8, volume: 22, anno: 1998,
pagine: 956 - 964
SICI:
0147-5185(1998)22:8<956:CPORAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; LYMPHADENOPATHY TYPE; CLASSIFICATION; EXPRESSION; FEATURES; NODES; DYSPROTEINEMIA; HISTOPATHOLOGY; DISORDERS; PATTERNS;
Keywords:
NON-HODGKINS LYMPHOMA; T CELL; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; FOLLICULAR DENDRITIC CELL; FIBROBLASTIC RETICULUM CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
D. Jones et al., "CHARACTERISTIC PROLIFERATIONS OF RETICULAR AND DENDRITIC CELLS IN ANGIOIMMUNOBLASTIC LYMPHOMA", The American journal of surgical pathology, 22(8), 1998, pp. 956-964

Abstract

Angioimmunoblastic lymphoma (AIL) is a T-cell proliferation with a distinct clinical presentation that often poses a difficult diagnostic challenge. Angioimmunoblastic lymphoma is characterized by prominent vascular and stromal proliferations. Using a panel of antibodies, we investigated the nature of the stromal component in 15 cases of AIL as compared with 40 cases of nodal-based peripheral T-cell lymphoma (PTCL) of other types. As has been previously noted, extrafollicular proliferations of follicular dendritic cells (detected by CD21 and low molecular-weight nerve growth factor receptor staining) were highly associated with AIL and were only rarely seen in other lesions. Unexpectedly, large networks of desmin-positive reticulum cells also were noted in all cases of AIL evaluated. These cells with characteristic lone cytoplasmic processes were present in much smaller numbers or only rarely in other types of peripheral T-cell lymphoma. This population of nodal stromal cells, a subset of the fibroblastic reticulum cells detected by vimentin immunostaining, may be responsible for the prominent reticulum deposition seen in An. No association of AIL with proliferations of other types of reticulum cells (e.g., interdigitating dendritic cells or histiocytes) was noted. These findings suggest that networks of follicular dendritic and desmin-positive reticulum cells are useful diagnostic features in angioimmunoblastic lymphoma and probably are relatedto the pathogenesis of this entity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:18:12