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Titolo:
RECOMBINANT FOWLPOX VIRUSES COEXPRESSING CHICKEN TYPE-I IFN AND NEWCASTLE-DISEASE VIRUS HN AND F GENES - INFLUENCE OF IFN ON PROTECTIVE EFFICACY AND HUMORAL RESPONSES OF CHICKENS FOLLOWING IN OVO OR POSTHATCH ADMINISTRATION OF RECOMBINANT VIRUSES
Autore:
KARACA K; SHARMA JM; WINSLOW BJ; JUNKER DE; REDDY S; COCHRAN M; MCMILLEN J;
Indirizzi:
UNIV MINNESOTA,COLL VET MED,DEPT PATHOBIOL ST PAUL MN 55108 UNIV MINNESOTA,COLL VET MED,DEPT PATHOBIOL ST PAUL MN 55108 SYNTRO RES LABS SAN DIEGO CA 92121 SYNTRO VET INC LENEXA KS 66219
Titolo Testata:
Vaccine
fascicolo: 16, volume: 16, anno: 1998,
pagine: 1496 - 1503
SICI:
0264-410X(1998)16:16<1496:RFVCCT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELOMONOCYTIC GROWTH-FACTOR; MAREKS-DISEASE; AVIAN INFLUENZA; HEMAGGLUTININ-NEURAMINIDASE; CONFERS PROTECTION; MOLECULAR-CLONING; POULTRY VACCINES; IMMUNE-RESPONSE; GLYCOPROTEIN-B; VIRAL VECTOR;
Keywords:
CHICKEN; RECOMBINANT FOWLPOX VIRUS; TYPE I INTERFERON; HEMAGGLUTININ-NEURAMINIDASE OF NEWCASTLE; DISEASE VIRUS; IN OVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
K. Karaca et al., "RECOMBINANT FOWLPOX VIRUSES COEXPRESSING CHICKEN TYPE-I IFN AND NEWCASTLE-DISEASE VIRUS HN AND F GENES - INFLUENCE OF IFN ON PROTECTIVE EFFICACY AND HUMORAL RESPONSES OF CHICKENS FOLLOWING IN OVO OR POSTHATCH ADMINISTRATION OF RECOMBINANT VIRUSES", Vaccine, 16(16), 1998, pp. 1496-1503

Abstract

We have constructed recombinant (r) fowl pox viruses (FPVs) coexpressing chicken type I interferon (IFN) and/or hemagglutinin-neuraminidase(HN) and fusion (F) proteins of Newcastle disease virus (NDV). We administered rFPVs and FPV into embryonated chicken eggs at 17 days of embryonation or in chickens after hatch. Administration of FPV or rFPVs did not influence hatchability and survival of hatched chicks. In ovo or after hatch vaccination of chickens with the recombinant viruses resulted in protection against challenge with virulent FPV and NDV. Chickens vaccinated with FPV or FPV-NDV recombinant had significant lower body weight 2 weeks following vaccination. This loss in body weight was not detected in chickens receiving FPV-IFN and FPV-NDI/-IFN recombinants. Chickens vaccinated with FPV coexpressing IFN and NDV genes produced less antibodies against NDV in k comparison with chickens vaccinated with FPV expressing NDVgenes. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:41:56