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Titolo:
ANTITUSSIVE ACTION OF ANTIHISTAMINES IS INDEPENDENT OF SEDATIVE AND VENTILATION ACTIVITY IN THE GUINEA-PIG
Autore:
MCLEOD RL; MINGO G; OREILLY S; RUCK L; BOLSER DC; HEY JA;
Indirizzi:
SCHERING PLOUGH CORP,INST RES,2015 GALLOPING HILL RD KENILWORTH NJ 07033
Titolo Testata:
Pharmacology
fascicolo: 2, volume: 57, anno: 1998,
pagine: 57 - 64
SICI:
0031-7012(1998)57:2<57:AAOAII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE H1-RECEPTOR ANTAGONIST; ALLERGIC RHINOCONJUNCTIVITIS; ORAL TERFENADINE; COUGH REFLEX; LORATADINE; PHARMACOLOGY; EFFICACY; SAFETY; ASTHMA;
Keywords:
COUGH; SEDATION; ANTIHISTAMINE; ETHANOLAMINE; ETHYLENEDIAMINE; PIPERIDINE; PIPERAZINE; PHENOTHIAZINE; ALKYLAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Mcleod et al., "ANTITUSSIVE ACTION OF ANTIHISTAMINES IS INDEPENDENT OF SEDATIVE AND VENTILATION ACTIVITY IN THE GUINEA-PIG", Pharmacology, 57(2), 1998, pp. 57-64

Abstract

We studied the oral actions of antihistamines from six chemical classes, namely: the ethanolamines (ENA, diphenhydramine and clemastine); ethylenediamines (EDA, pyrilamine and tripelennamine); piperidines (PPD, terfenadine and astemizole); piperazines (PPZ, hydroxyzine and cetirizine); phenothiazines (PTZ, promethazine), and the alkylamines (ALA, chlorpheniramine and bromopheniramine) on cough reflexes, pentobarbital-induced sedation and minute ventilation in the conscious guinea pig. Antihistamines of the ENA class had minimal effects on capsaicin-induced cough although both diphenhydramine (30 and 100 mg/kg p.o.) and clemastine (30 and 100; mg/kg p.o.) increased sedation time (ST). The PPZ class demonstrated both antitussive and sedating activity. The minimum effective oral antitussive dose (MED) of cetirizine and hydroxyzinewas 30 and 10 mg/kg, respectively. The EDA did not exhibit antitussive activity. Tripelennamine (10, 30 and 100 mg/kg p.o.) but not pyrilamine enhanced ST. The MEU for the PTZ, promethazine, was 10 mg/kg, and at 100 mg/kg promethazine increased ST. The ALA group displayed antitussive activity but only chlorpheniramine (10 mg/kg p.o.) had ally effects on ST. The MED for chlorpheiniramine and bromopheniramine was 3 and 10 mg/kg p.o., respectively. The PPD antihistamines, namely terfenadine and astemizole, inhibited cough (MED 30 and 10 mg/kg p.o.) withoutsedative effects. Of the antihistamines tested only promethazine (100mg/kg p.o.) depressed ventilation responses; however, this dose of promethazine was associated with adverse behavioral effects. The presentfindings indicate that the antitussive act:ions of antihistamines arenot directly related to histamine H-1-receptor blockade because several antihistamines did not antagonize capsaicin-induced cough. In addition, the antitussive actions of antihistamines are independent of their sedative or ventilation effects.

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Documento generato il 15/01/21 alle ore 18:26:56