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Titolo:
DUCTAL CARCINOMA IN SITU-ASSOCIATED NIPPLE DISCHARGE - A CLINICAL MARKER FOR LOCALLY EXTENSIVE DISEASE
Autore:
BAUER RL; ECKHERT KH; NEMOTO T;
Indirizzi:
BREAST HLTH ASSOCIATES,55 SPINDRIFT DR WILLIAMSVILLE NY 14221 SUNY BUFFALO,SISTERS CHAR HOSP,DEPT SURG BUFFALO NY 14260
Titolo Testata:
Annals of surgical oncology
fascicolo: 5, volume: 5, anno: 1998,
pagine: 452 - 455
SICI:
1068-9265(1998)5:5<452:DCISND>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CONSERVING SURGERY; INTRADUCTAL CARCINOMA; DEFINITIVE IRRADIATION; MANAGEMENT; CANCER; BIOPSY;
Keywords:
DUCTAL CARCINOMA IN SITU; NIPPLE DISCHARGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Bauer et al., "DUCTAL CARCINOMA IN SITU-ASSOCIATED NIPPLE DISCHARGE - A CLINICAL MARKER FOR LOCALLY EXTENSIVE DISEASE", Annals of surgical oncology, 5(5), 1998, pp. 452-455

Abstract

Background: This study evaluates the diagnosis and treatment of womenwith pathologic nipple discharge caused by ductal carcinoma in situ (DCIS). Methods: Women with unilateral spontaneous bloody, serous, or brown nipple discharge who presented between January 1, 1988 and August1, 1996 were identified by retrospective chart review. Women with nonspontaneous, physiologic discharge were excluded. Results: Two hundredseventy-seven women with a mean age of 59.5 years (range, 24 to 88 years) underwent duct exploration and biopsy for pathologic discharge, with 43 (15.5%) found to have DCIS. The discharge was bloody in 29, clear in eight, and brown in six women. Seven of 12 (58%) women with an associated breast mass were found to have a microinvasive component with the DCIS. Discharge cytology showed malignant cells in only two of 12 (16%) women examined. A ductogram was performed on 20 women, with filling defects seen in 10, ectasia in 3, narrowing in 4, and normal ducts in 3. The DCIS included 17 (40%) specimens with cribriform, pattern, 17 (40%) micropapillary, 8 (18%) comedo, and 2 (2%) solid. Twelve microinvasive cancers were found in combination with DCIS. After duct exploration, 37 (86%) patients were found to have extensive or multifocal DCIS to the margin, or both, with 32 (74%) patients requiring mastectomy to achieve free surgical margins. There was residual disease in 27 of 32 (84%) mastectomy specimens after initial biopsy. Breast conservation was possible in only 11 (26%) women. Forty of 43 (93%) are disease-free with a median follow-up of 37 months. Conclusion: Women presenting with pathologic nipple discharge require duct exploration regardless of cytologic or radiologic findings. When discharge is the resultof DCIS, extensiveness of disease in relation to central location andintraductal spread may preclude breast conservation in as many as 27 of 43 (63%) cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:57:15