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Titolo:
PLACENTAL PATHOLOGY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROSPECTIVE-STUDY
Autore:
MAGID MS; KAPLAN C; SAMMARITANO LR; PETERSON M; DRUZIN ML; LOCKSHIN MD;
Indirizzi:
MT SINAI MED CTR,DEPT PATHOL,BOX 1194,1 GUSTAVE L LEVY PL NEW YORK NY10029 CORNELL UNIV,MED CTR,NEW YORK HOSP,HOSP SPECIAL SURG,DEPT PATHOL NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,HOSP SPECIAL SURG,DEPT OBSTET & GYNECOL NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,HOSP SPECIAL SURG,DIV RHEUMAT DIS NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,HOSP SPECIAL SURG,DEPT BIOMECH & BIOMAT NEW YORK NY 10021 SUNY STONY BROOK,UNIV HOSP,DEPT PATHOL STONY BROOK NY 11794
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 179, anno: 1998,
pagine: 226 - 234
SICI:
0002-9378(1998)179:1<226:PPISL->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICOAGULANT PROTEIN-I; ANTIPHOSPHOLIPID ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; DECIDUAL VASCULOPATHY; FETAL LOSS; PREGNANCY; WOMEN; INFARCTION; ABORTION; PATIENT;
Keywords:
PLACENTA; SYSTEMIC LUPUS ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODY; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Magid et al., "PLACENTAL PATHOLOGY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROSPECTIVE-STUDY", American journal of obstetrics and gynecology, 179(1), 1998, pp. 226-234

Abstract

OBJECTIVES: Systemic lupus erythematosus and antiphospholipid antibody, often identified in patients with systemic lupus erythematosus, areassociated with poor pregnancy outcome. This study distinguishes between the effect of each of these factors on gestational outcome and placental pathologic conditions in pregnant patients with systemic lupus erythematosus. STUDY DESIGN: Thirty-seven pregnancies and 40 placentasfrom 33 women with systemic lupus erythematosus were studied prospectively. RESULTS: Systemic lupus erythematosus alone, but not systemic lupus erythematosus activity, was associated with increased spontaneousabortions, preterm gestations, and fetal growth restriction. Placental correlates were ischemic-hypoxic change, decidual vasculopathy, decidual and fetal thrombi, chronic villitis, and decreased placental weight. Extensive infarction and fetal death were important antiphospholipid antibody-related findings. CONCLUSIONS: Decidual vasculopathy/coagulopathy appears to mediate the antiphospholipid antibody-related and much of the systemic lupus erythematosus-related deleterious effect on the placenta and gestational outcome. The presence of antiphospholipidantibody largely, but not invariably, predicts fetal death. Antiphospholipid antibody-independent chronic villitis may represent a second mechanism of systemic lupus erythematosus-related change.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:36:28