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Titolo:
LONGITUDINAL CHANGES IN BODY-COMPOSITION AND ENERGY-BALANCE IN LEAN WOMEN WITH NORMAL AND ABNORMAL GLUCOSE-TOLERANCE DURING PREGNANCY
Autore:
CATALANO PM; ROMANDRAGO NM; AMINI SB; SIMS EAH;
Indirizzi:
CASE WESTERN RESERVE UNIV,METROHLTH MED CTR,DEPT REPROD BIOL,2500 METROHEALTH DR CLEVELAND OH 44109 UNIV VERMONT,COLL MED,DEPT MED,ENDOCRINE METAB UNIT BURLINGTON VT 05405
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 179, anno: 1998,
pagine: 156 - 165
SICI:
0002-9378(1998)179:1<156:LCIBAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIMA-INDIANS; WEIGHT-GAIN; REQUIREMENTS; INSULIN; RATES;
Keywords:
PREGNANCY; INSULIN RESISTANCE; ENERGY EXPENDITURE; BODY COMPOSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Catalano et al., "LONGITUDINAL CHANGES IN BODY-COMPOSITION AND ENERGY-BALANCE IN LEAN WOMEN WITH NORMAL AND ABNORMAL GLUCOSE-TOLERANCE DURING PREGNANCY", American journal of obstetrics and gynecology, 179(1), 1998, pp. 156-165

Abstract

OBJECTIVE: The objective of this study was to evaluate the longitudinal changes in energy expenditure and body composition in relationship to alterations in carbohydrate metabolism in women with normal and abnormal glucose metabolism. We hypothesized that women with decreased insulin sensitivity before conception would have less fat accretion and smaller increases in energy expenditure. STUDY DESIGN: Six women with normal glucose tolerance and 10 women with abnormal glucose tolerance were evaluated before conception, and in early (12 to 14 weeks) and late (34 to 36 weeks) gestation. Body composition was estimated by hydrodensitometry, resting energy expenditure, and glucose and fat metabolism by indirect calorimetry, endogenous glucose production by infusion of [6-6 H-2(2)] glucose, and insulin sensitivity using a hyperinsulinemic-euglycemic clamp (40 mU/m(2)/min). RESULTS: There was a smaller increase in fat mass (1.3 kg [P = .04]) in early pregnancy in women withabnormal glucose tolerance before pregnancy. Indirect calorimetry measured gestational age-related increases in basal oxygen utilization, with or without correction for fat-free mass ((V)over dot O-2, P = .002), resting energy expenditure (expressed in kilocalories, P = .0001), and carbohydrate oxidation (P = .0003). The insulin-mediated elevationin (V)over dot O-2 increased in later gestation (V)over dot O-2 (P = .005), as did resting energy expenditure (P = .0001) and fat oxidation(P = 0.0001). However, there was a decrease in respiratory quotient (P = .0001), carbohydrate oxidation (P = .002), and nonoxidative carbohydrate metabolism (P = .0001) with advancing gestation during insulin infusion. in early pregnancy, changes in fat mass correlated inverselywith changes in insulin sensitivity (r = -0.52, P = .04) and changes in basal (V)over dot O-2 correlated inversely with decreases in basal endogenous glucose production (r = -0.74, P = .01). CONCLUSION: In early gestation, the changes in maternal fat mass and basal oxygen consumption are inversely related to the changes in insulin sensitivity. This response in lean women with decreased insulin sensitivity before conception may have survival value by providing a larger amount of available substrate to meet fetoplacental needs during gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:59:46