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Titolo:
LEFT-VENTRICULAR DIASTOLIC FILLING IN THE ELDERLY - THE CARDIOVASCULAR HEALTH STUDY
Autore:
GARDIN JM; ARNOLD AM; BILD DE; SMITH VE; LIMA JAC; KLOPFENSTEIN HS; KITZMAN DW;
Indirizzi:
CHS COORDINATING CTR,CENTURY SQ,1501 4TH AVE,SUITE 2105 SEATTLE WA 98101 UNIV CALIF IRVINE,DEPT MED,DIV CARDIOL IRVINE CA 92717 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 ALBANY MED COLL,DIV CARDIOL ALBANY NY 12208 JOHNS HOPKINS MED INST,DEPT MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT EPIDEMIOL BALTIMORE MD 21205 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MED,DIV CARDIOL WINSTON SALEM NC 27103
Titolo Testata:
The American journal of cardiology
fascicolo: 3, volume: 82, anno: 1998,
pagine: 345 - 351
SICI:
0002-9149(1998)82:3<345:LDFITE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED SYSTOLIC HYPERTENSION; CONGESTIVE HEART-FAILURE; ECHOCARDIOGRAPHIC ASSESSMENT; DISEASE; INDEXES; MILD; MASS; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Gardin et al., "LEFT-VENTRICULAR DIASTOLIC FILLING IN THE ELDERLY - THE CARDIOVASCULAR HEALTH STUDY", The American journal of cardiology, 82(3), 1998, pp. 345-351

Abstract

Changes in left ventricular (LV) diastolic function (e.g.., as measured by transmitral flow velocity) are known to occur with aging. In addition, impaired LV diastolic function plays an important role in such cardiovascular disorders common in the elderly as hypertension, ischemic heart disease, and congestive heart failure (CHF). Participants in the Cardiovascular Health Study, a multicenter study of community-dwelling men (n = 2,239) and women (n = 2,962) greater than or equal to 65years of age, underwent an extensive baseline evaluation, including echocardiography. Early diastolic LV Doppler (transmitral) peak fillingvelocity decreased, and peak late diastolic (atrial) velocity increased with age in multivariate analyses tall p <0.001). Early and late diastolic peak filling velocities were both significantly higher in women than in men, even after adjustment for body surface area (or height and weight). In multivariate models in the entire cohort and a healthysubgroup (n = 703), gender, age, heart rate, and blood pressure (BP) were most strongly related to early and late diastolic transmitral peak velocities. Early and late diastolic peak velocities both increased with increases in systolic BP and decreased with increases in diastolic BP (p <0.001). Doppler transmitral velocities were compared among health status subgroups. In multiple regression models adjusted for other covariates, and in analysis of variance models examining differencesacross subgroups adjusted only for age, the subgroup with CHF had thehighest early diastolic peak velocities. All clinical disease subgroups had higher late diastolic peak velocities than the healthy subgroup, with the subgroups with either CHF or hypertension having the highest age-adjusted means. The subgroup with hypertension had the lowest ratio of early-to-late diastolic peak velocity, and men with CHF had thehighest ratio. These findings are consistent with previous reports that hypertensive subjects exhibit an abnormal relaxation pattern, whereas patients with CHF develop a pattern suggestive of an increased early diastolic left atrial-LV pressure gradient. (C)1998 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:11:42