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Titolo:
FREQUENT REARRANGEMENTS OF CHROMOSOME-1, CHROMOSOME-7, AND CHROMOSOME-8 IN PRIMARY LIVER-CANCER
Autore:
PARADA LA; HALLEN M; TRANBERG KG; HAGERSTRAND I; BONDESON L; MITELMAN F; JOHANSSON B;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN GENET S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT PATHOL S-22185 LUND SWEDEN MALMO UNIV HOSP,DEPT PATHOL MALMO SWEDEN
Titolo Testata:
Genes, chromosomes & cancer
fascicolo: 1, volume: 23, anno: 1998,
pagine: 26 - 35
SICI:
1045-2257(1998)23:1<26:FROCCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEPATOCELLULAR CARCINOMAS; IN-SITU HYBRIDIZATION; HETEROZYGOSITY; GENE; TUMORS; HEPATOCARCINOGENESIS; ABNORMALITIES; ABERRATIONS; PROGRESSION; HYPERPLASIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Parada et al., "FREQUENT REARRANGEMENTS OF CHROMOSOME-1, CHROMOSOME-7, AND CHROMOSOME-8 IN PRIMARY LIVER-CANCER", Genes, chromosomes & cancer, 23(1), 1998, pp. 26-35

Abstract

Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detectedin four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, and 8 and chromosomebands 1p36, 1q25, 3q10, 5q13, 6p10, 7p15, 7q22, 7q32, 8q10, 8q13, 14q10, and 17p11. Frequent genomic imbalances included gains of 1q, 3q, 6p, 7p, and 8q and losses of 1p, 8p, 10q, 14p, 17p, and 19p. A compilation of findings for all 19 cytogenetically abnormal PLCs reported to date, including the present cases, reveals that structural aberrations particularly affect 1p11, 1p22, 1p32, 1p34, 1p36, 1q25, 7p15, 7q22, 8q10, 8q13, 14q10, 16q24, and 17p11, and that the abnormalities frequently result in overrepresentation of 1q, 3q, 6p, 7p10-14, 8q, and 17q and underrepresentation of 1p34-36, 6q27, 7q32-qter, 8p, 13p, 14p, 16q24, and 17p. These genomic regions are likely to harbor genes of importance in hepatocarcinogenesis, and the present cytogenetic mapping may hence be of value for further molecular genetic investigations of PLC. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:06:45