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Titolo:
DIRECT MEASUREMENT OF PULMONARY MICROVASCULAR DISTENSIBILITY
Autore:
HILLIER SC; GODBEY PS; HANGER CC; GRAHAM JA; PRESSON RG; OKADA O; LINEHAN JH; DAWSON CA; WAGNER WW;
Indirizzi:
RILEY CHILDRENS HOSP,DEPT ANESTHESIA & CRIT CARE,702 BARNHILL DR,ROOM2001 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT ANESTHESIA INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHYSIOL BIOPHYS INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PEDIAT INDIANAPOLIS IN 46202 MED COLL WISCONSIN,DEPT PHYSIOL MILWAUKEE WI 53226 CLEMENT J ZEBLOCKI VET ADM CTR,RES SERV MILWAUKEE WI 53233
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 75, anno: 1993,
pagine: 2106 - 2111
SICI:
8750-7587(1993)75:5<2106:DMOPMD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VESSELS; DOG LUNG; ELASTICITY; PRESSURE; FLOW; RECRUITMENT; VEINS; MODEL;
Keywords:
PULMONARY CIRCULATION; PULMONARY VASCULAR DISTENSIBILITY; PULMONARY MICROCIRCULATION; ARTERIOLES; VENULES; VIDEOMICROSCOPY; DOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Hillier et al., "DIRECT MEASUREMENT OF PULMONARY MICROVASCULAR DISTENSIBILITY", Journal of applied physiology, 75(5), 1993, pp. 2106-2111

Abstract

Pulmonary vascular distensibility has an important influence on pulmonary hemodynamics. Although many measurements of distensibility have been made on large pulmonary vessels, there is less information on microvascular distensibility. We have measured the distensibility of the smallest (<70-mum-diam) precapillary arterioles and postcapillary venules. Isolated dog lobes, at 2.5 cmH2O transpulmonary pressure, were perfused at low flows, which caused the arteriovenous pressure gradient to be very small and thereby permitted accurate estimation of microvascular pressure. As microvascular pressure was systematically varied between 0 and 30 mmHg, subpleural microvascular diameters were determinedfrom computer-enhanced images obtained by videomicroscopy. Arteriolarand venular distensibilities were not different from each other. The microvascular pressure-diameter relationship was alinear with distensibility coefficients of 1-3% mmHg-1, values that are of the same order of magnitude as previously measured distensibilities of 100- to 1,000-mum-diam canine pulmonary vessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:56:30