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Titolo:
HUMAN INTERFERON-GAMMA-INDUCIBLE PROTEIN-10 (IP-10) INHIBITS CONSTITUTIVE SIGNALING OF KAPOSIS-SARCOMA ASSOCIATED HERPESVIRUS G-PROTEIN COUPLED RECEPTOR
Autore:
GERASRAAKA E; VARMA A; HO H; CLARKLEWIS I; GERSHENGORN MC;
Indirizzi:
CORNELL UNIV,COLL MED,DEPT MED,DIV MOL MED NEW YORK NY 10021 UNIV BRITISH COLUMBIA,BIOMED RES CTR VANCOUVER BC V6T 1Z4 CANADA
Titolo Testata:
The Journal of experimental medicine
fascicolo: 2, volume: 188, anno: 1998,
pagine: 405 - 408
SICI:
0022-1007(1998)188:2<405:HIP(IC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-8; ANTAGONISTS; LYMPHOMA;
Keywords:
HUMAN MONOKINE INDUCED BY INTERFERON GAMMA; C-X-C CHEMOKINE RECEPTOR 3; INVERSE AGONIST; HUMAN HERPESVIRUS 8; TUMORIGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E. Gerasraaka et al., "HUMAN INTERFERON-GAMMA-INDUCIBLE PROTEIN-10 (IP-10) INHIBITS CONSTITUTIVE SIGNALING OF KAPOSIS-SARCOMA ASSOCIATED HERPESVIRUS G-PROTEIN COUPLED RECEPTOR", The Journal of experimental medicine, 188(2), 1998, pp. 405-408

Abstract

A G protein-coupled receptor (GPCR) is encoded within the genome of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that may be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas. KSHV-GPCR exhibits constitutive signaling activity that causes oncogenic transformation. We report that human interferon (IFN)-gamma-inducible protein 10 (HuIP-10), a C-X-C chemokine, specifically inhibits signaling of KSHV-GPCR. In contrast, monokine induced by IFN-gamma (HuMig), which like HuIP-10 is an agonist of C-X-C chemokine receptor 3, does not inhibit KSHV-GPCR signaling. Moreover, HuIP-10, but not HuMig, inhibits KSHV-GPCR-induced proliferation of NIH 3T3 cells. These results show that HuIP-10 is an inverse agonist that converts KSHV-GPCR fron; an active to an inactive state. Thus, a human chemokine inhibits constitutive signaling and cellular proliferation that is mediated by a receptor encoded by a human disease-associated herpesvirus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:14:50