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Titolo:
CD4 T-CELL CYTOKINE DIFFERENTIATION - THE B-CELL ACTIVATION MOLECULE,OX40 LIGAND, INSTRUCTS CD4 T-CELLS TO EXPRESS INTERLEUKIN-4 AND UP-REGULATES EXPRESSION OF THE CHEMOKINE RECEPTOR, BLR-1
Autore:
FLYNN S; TOELLNER KM; RAYKUNDALIA C; GOODALL M; LANE P;
Indirizzi:
UNIV BIRMINGHAM SCH MED,DEPT IMMUNOL,VINCENT DR BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM SCH MED,DEPT IMMUNOL BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
The Journal of experimental medicine
fascicolo: 2, volume: 188, anno: 1998,
pagine: 297 - 304
SICI:
0022-1007(1998)188:2<297:CTCD-T>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; IL-4; LIGATION; PROTEIN;
Keywords:
TH1-TH2 DIFFERENTIATION; OX40 OX40 LIGAND; CYTOKINE; T CELL PRIMING; COGNATE B CELL T CELL INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Flynn et al., "CD4 T-CELL CYTOKINE DIFFERENTIATION - THE B-CELL ACTIVATION MOLECULE,OX40 LIGAND, INSTRUCTS CD4 T-CELLS TO EXPRESS INTERLEUKIN-4 AND UP-REGULATES EXPRESSION OF THE CHEMOKINE RECEPTOR, BLR-1", The Journal of experimental medicine, 188(2), 1998, pp. 297-304

Abstract

This report investigates the role of OX40 ligand (OX40L) and its receptor, OX40, expressed on activated B and T cells, respectively, in promoting the differentiation of T helper type 2 (Th2) CD4 T cells. Thesemolecules are expressed in vivo by day 2 after priming with T cell-dependent antigens. Their expression coincides with the appearance of immunoglobulin (Ig)G switch transcripts and mRNA for interleukin (IL)-4 and interferon (IFN)-gamma, suggesting that this molecular interactionplays a role in early cognate interactions between B and T cells. In vitro, we report that costimulation of naive, CD62L(high) CD4 T cells through OX40 promotes IL-4 expression and upregulates mRNA for the chemokine receptor, blr-1, whose ligand is expressed in B follicles and attracts lymphocytes to this location. Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both CD8 T cells and IL-12-stimulated CD4 T cells. Although this signal initiates IL-4 expression, IL-4 itself is strongly synergistic. Our data suggest that OX40L on antigen-activated B cells instructs naive T cells to differentiate into Th2 cells and migrate into B follicles, where T cell-dependent germinal centers develop.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 05:52:42