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Titolo:
DOSE-DEPENDENT RESPONSE OF VESTIBULAR HAIR-CELLS OF GUINEA-PIGS FOLLOWING STREPTOMYCIN OTOTOXIATION
Autore:
NAKAGAWA T; YAMANE H; TAKAYAMA M; SUNAMI K; NAKAI Y;
Indirizzi:
YODOGAWA CHRISTIANS HOSP,DEPT OTORHINOLARYNGOL,2-9-26 AWAJI HIGASHIYODOGAWAKU OSAKA 533 JAPAN OSAKA CITY UNIV,SCH MED OSAKA 545 JAPAN
Titolo Testata:
Acta oto-laryngologica
fascicolo: 4, volume: 118, anno: 1998,
pagine: 530 - 533
SICI:
0001-6489(1998)118:4<530:DROVHO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER-EAR; SENSORY EPITHELIA; NEURONAL DEATH; APOPTOSIS; NECROSIS; TOXICITY;
Keywords:
AMPULLAR CRISTA; AMINOGLYCOSIDE; APOPTOSIS; HAIR CELL DEGENERATION; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakagawa et al., "DOSE-DEPENDENT RESPONSE OF VESTIBULAR HAIR-CELLS OF GUINEA-PIGS FOLLOWING STREPTOMYCIN OTOTOXIATION", Acta oto-laryngologica, 118(4), 1998, pp. 530-533

Abstract

Although the involvement of apoptosis has been suggested in the loss of vestibular hair cells due to aminoglycosides, dose-dependent effects of aminoglycosides have not been determined. We therefore examined dose-dependent effects of streptomycin on the degeneration of hair cells of guinea pig ampullar cristae using TUNEL stain and Hoechst nuclearstain. Streptomycin induced apoptosis of hair cells in a dose-dependent manner. Even following high-dose applications, most of the affectedcells showed apoptotic features. Apoptosis may therefore play a predominant role in the deletion of vestibular hair cells affected by aminoglycosides.

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Documento generato il 02/12/20 alle ore 07:04:51