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Titolo:
A GENE ENCODING THE PLANT-LIKE ALTERNATIVE OXIDASE IS PRESENT IN PHYTOMONAS BUT ABSENT IN LEISHMANIA SPP
Autore:
VANHELLEMOND JJ; SIMONS B; MILLENAAR FF; TIELENS AGM;
Indirizzi:
UNIV UTRECHT,VET BIOCHEM LAB,POB 80176 NL-3508 TD UTRECHT NETHERLANDS UNIV UTRECHT,VET BIOCHEM LAB NL-3508 TD UTRECHT NETHERLANDS UNIV UTRECHT,INST BIOMEMBRANES NL-3508 TD UTRECHT NETHERLANDS UNIV UTRECHT,FAC BIOL,DEPT PLANT ECOL & EVOLUT BIOL NL-3508 TD UTRECHT NETHERLANDS
Titolo Testata:
The Journal of eukaryotic microbiology
fascicolo: 4, volume: 45, anno: 1998,
pagine: 426 - 430
SICI:
1066-5234(1998)45:4<426:AGETPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPANOSOMA-BRUCEI-BRUCEI; BLOOD-STREAM; EUPHORBIA-CHARACIAS; RESPIRATORY-CHAIN; IDENTIFICATION; FORMS; PROMASTIGOTES; METABOLISM; ALIGNMENT; DONOVANI;
Keywords:
ELECTRON-TRANSPORT CHAIN; RESPIRATION; SALICYLHYDROXAMIC ACID; TRYPANOSOMATIDAE; UBIQUINONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Vanhellemond et al., "A GENE ENCODING THE PLANT-LIKE ALTERNATIVE OXIDASE IS PRESENT IN PHYTOMONAS BUT ABSENT IN LEISHMANIA SPP", The Journal of eukaryotic microbiology, 45(4), 1998, pp. 426-430

Abstract

The constituents of the respiratory chain are believed to differ among the trypanosomatids; bloodstream stages of African trypanosomes and Phytomonas promastigotes oxidize ubiquinol by a ubiquinol:oxygen oxidoreductase, also known as alternative oxidase, whereas Leishmania spp. oxidize ubiquinol via a classic cytochrome-containing respiratory chain. The molecular basis for this elementary difference in ubiquinol oxidation by the mitochondrial electron-transport chain in distinct trypanosomatids was investigated. The presence of a gene encoding the plant-like alternative oxidase could be demonstrated in Phytomonas and Trypanosoma brucei, trypanosomatids that are known to contain alternative oxidase activity. Our results further demonstrated that Leishmania spp. lack a gene encoding the plant-like alternative oxidase, and therefore, all stages of Leishmania spp. will lack the alternative oxidase protein. The observed fundamental differences between the respiratory chains of distinct members of the trypanosomatid family are thus caused by the presence or absence of a gene encoding the plant-like alternative oxidase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:08:05