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Titolo:
ZAPRINAST, A TYPE-V PHOSPHODIESTERASE INHIBITOR, DILATES CAPACITANCE VESSELS IN ANESTHETIZED RATS
Autore:
NG SSW; PANG CCY;
Indirizzi:
UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL VANCOUVER BC V6T 1Z3 CANADA UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT VANCOUVER BCV6T 1Z3 CANADA
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 351, anno: 1998,
pagine: 323 - 328
SICI:
0014-2999(1998)351:3<323:ZATPID>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CIRCULATORY FILLING PRESSURE; NITRO-L-ARGININE; CONSCIOUS RATS; SMOOTH-MUSCLE; VENOUS TONE; SELECTIVE INHIBITORS; RABBIT AORTA; ANTAGONISTS; TOLERANCE;
Keywords:
ZAPRINAST; PHOSPHODIESTERASE, CGMP-SELECTIVE; CIRCULATORY FILLING PRESSURE, MEAN; ARTERIAL RESISTANCE; VENOUS RESISTANCE; CAPACITANCE VESSEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.S.W. Ng e C.C.Y. Pang, "ZAPRINAST, A TYPE-V PHOSPHODIESTERASE INHIBITOR, DILATES CAPACITANCE VESSELS IN ANESTHETIZED RATS", European journal of pharmacology, 351(3), 1998, pp. 323-328

Abstract

The effects of zaprinast (a type V phosphodiesterase inhibitor) on mean arterial pressure, heart rate, cardiac output, mean circulatory filling pressure, arterial and venous resistances were compared to those of sodium nitroprusside in three groups, each of intact or ganglion-blocked, Inactin-anaesthetised rats. In intact rats, zaprinast (1.5, 3.0mg kg(-1) min(-1)) and sodium nitroprusside (8.0, 64.0 mu g kg(-1) min(-1)) dose-dependently reduced mean arterial pressure and arterial resistance, but did not alter cardiac output and venous resistance. Bothincreased heart rate, with the effect of zaprinast less than that of sodium nitroprusside. Mean circulatory filling pressure was elevated by both doses of zaprinast but only the high dose of sodium nitroprusside. In rats given mecamylamine (3.7 mu mol kg(-1), i.v. bolus) and noradrenaline (7.3 nmol kg(-1) min(-1)), zaprinast and sodium nitroprusside elicited dose-dependent reductions in mean arterial pressure, arterial and venous resistances, and mean circulatory filling pressure. Both increased cardiac output, with the effect of zaprinast greater than that of sodium nitroprusside at the low dose. Zaprinast but not sodiumnitroprusside reduced heart rate. Our results indicate that zaprinast, similar to sodium nitroprusside, dilates both resistance and capacitance vessels in ganglion-blocked rats infused with noradrenaline to restore vasomotor tone. Zaprinast but not sodium nitroprusside has a direct, negative chronotropic effect on the heart. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:32:11