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Titolo:
DOPAMINE D-2 AND D-4 RECEPTOR LIGANDS - RELATION TO ANTIPSYCHOTIC ACTION
Autore:
WILSON JM; SANYAL S; VANTOL HHM;
Indirizzi:
CLARKE INST PSYCHIAT,LAB MOL NEUROBIOL 3,250 COLL ST TORONTO ON M5T 1R8 CANADA CLARKE INST PSYCHIAT,LAB MOL NEUROBIOL 3 TORONTO ON M5T 1R8 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO ON CANADA UNIV TORONTO,INST MED SCI TORONTO ON CANADA
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 351, anno: 1998,
pagine: 273 - 286
SICI:
0014-2999(1998)351:3<273:DDADRL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; INSITU HYBRIDIZATION HISTOCHEMISTRY; C-11 N-METHYLSPIPERONE; GUINEA-PIG BRAIN; RAT-BRAIN; MESSENGER-RNA; D2-DOPAMINE RECEPTOR; MOLECULAR-CLONING; D4 RECEPTORS;
Keywords:
ANTIPSYCHOTIC; CLOZAPINE; SCHIZOPHRENIA; DOPAMINE D-4 RECEPTOR ANTAGONIST; NEUROLEPTIC LOOSE; DOPAMINE RECEPTOR; EXTRAPYRAMIDAL SYMPTOM; DOPAMINE D-2-LIKE RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
123
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Wilson et al., "DOPAMINE D-2 AND D-4 RECEPTOR LIGANDS - RELATION TO ANTIPSYCHOTIC ACTION", European journal of pharmacology, 351(3), 1998, pp. 273-286

Abstract

Since the discovery that the antipsychotic action of phenothiazines was mediated by dopamine D-2 receptors, the dopamine system has been scrutinized for schizophrenia related abnormalities. The focus has been to create neuroleptics with improved antipsychotic profiles and reduced side effects. With the identification of multiple dopamine receptor subtypes, the hypotheses regarding the role of dopamine in schizophrenia and antipsychotic action of neuroleptics have been refined. Even after the molecular identification of newer dopamine D-2-like receptor subtypes (D-3 and D-4), the dopamine D-2 receptor is still considered the predominant site for antipsychotic action. However, there has been much debate concerning the modulatory role of other dopamine receptor sites in the mechanism of action of antipsychotic drugs. Specifically,the dopamine D-4 receptor has received much attention in this regard,since the atypical antipsychotic agent, clozapine, preferentially blocks this receptor subtype as compared with dopamine D-2 and D-3 receptors. In this review we will highlight some of the observations and arguments regarding the involvement of the dopamine D-2 and D-4 receptor sites in the therapeutic efficacy of antipsychotic medication. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:46:31