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Titolo:
HIGH-THROUGHPUT APPROACHES FOR EVALUATING ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION PROPERTIES OF LEAD COMPOUNDS
Autore:
TARBIT MH; BERMAN J;
Indirizzi:
GLAXO WELLCOME RES & DEV LTD,BIOMET DIV,INT SCI DEV GRP,PARK RD WARE SG12 0DP HERTS ENGLAND GLAXO WELLCOME INC,DIV CHEM RES TRIANGLE PK NC 27709
Titolo Testata:
Current opinion in chemical biology
fascicolo: 3, volume: 2, anno: 1998,
pagine: 411 - 416
SICI:
1367-5931(1998)2:3<411:HAFEAD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; PARAMETERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Tarbit e J. Berman, "HIGH-THROUGHPUT APPROACHES FOR EVALUATING ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION PROPERTIES OF LEAD COMPOUNDS", Current opinion in chemical biology, 2(3), 1998, pp. 411-416

Abstract

Combinatorial chemistry methods and high-throughput screening for leads in industrial drug discovery have generated a potential bottleneck in the optimisation processes that seek to align potency with good pharmacokinetics in order to produce good medicines. This has resulted inthe need for higher throughput methods of screening for absorption, distribution, metabolism and excretion properties. Significant progresshas been made in throughput of in vivo pharmacokinetic studies, with the introduction of cassette, or multiple-in-one, protocols. In this technique, typically up to ten compounds are administered in one dose and analysed concomitantly on the mass spectrometer. High-throughput methods in in vitro absorption, distribution, metabolism and excretion are less well-developed as yet, and current approaches comprise automation of well-established methods for absorption using cell lines and metabolism using liver microsomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:11:35