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Titolo:
IN-VIVO ASSOCIATION BETWEEN ALCOHOL-INTOXICATION, AGGRESSION, AND SEROTONIN TRANSPORTER AVAILABILITY IN NONHUMAN-PRIMATES
Autore:
HEINZ A; HIGLEY JD; GOREY JG; SAUNDERS RC; JONES DW; HOMMER D; ZAJICEK K; SUOMI SJ; LESCH KP; WEINBERGER DR; LINNOILA M;
Indirizzi:
RUHR UNIV BOCHUM,ST JOSEF HOSP,DEPT NEUROL,GUDRUNSTR 56 D-44791 BOCHUM GERMANY ST ELIZABETH HOSP,CLIN BRAIN DISORDERS BRANCH,NIMH,CTR NEUROSCI WASHINGTON DC 00000 NIAAA BETHESDA MD 00000 UNIV WURZBURG,DEPT PSYCHIAT D-8700 WURZBURG GERMANY
Titolo Testata:
The American journal of psychiatry
fascicolo: 8, volume: 155, anno: 1998,
pagine: 1023 - 1028
SICI:
0002-953X(1998)155:8<1023:IABAAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; 5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; DIMINISHED SOCIAL COMPETENCE; I-123 BETA-CIT; RHESUS-MONKEYS; IN-VIVO; PREFERRING P; METABOLITES; DOPAMINE; PERSONALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Heinz et al., "IN-VIVO ASSOCIATION BETWEEN ALCOHOL-INTOXICATION, AGGRESSION, AND SEROTONIN TRANSPORTER AVAILABILITY IN NONHUMAN-PRIMATES", The American journal of psychiatry, 155(8), 1998, pp. 1023-1028

Abstract

Studies on brain serotonin metabolism in human and nonhuman primates have indicated that dysfunction of serotonin transmission may play a role in the biological vulnerability to dependence on alcohol. Among young men, low sensitivity to alcohol intoxication predicts subsequent alcohol abuse and dependence. Method: The authors used single photon emission computed tomography and the radioligand [(I)123] beta-CIT ([(I)123]methyI 3 beta-(4-iodophenyl) tropane-2-carboxylate) to measure theavailability of serotonin transporters in 11 male rhesus monkeys, andthe monkeys were genotyped for a functional polymorphism of the serotonin transporter gene. The 11 monkeys had experienced parental separation after birth; their behavior and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in CSF had been assessed regularly. Results: In the 5-year-old monkeys, there was a significant negative correlation between beta-GIT binding to serotonin transporters in the brainstem and 5-HIAA concentrations in CSF. Animals with greater beta-CIT binding and low CSF 5-HIAA concentrations displayed greater aggressiveness and were less sensitive to alcohol-induced intoxication. The genetic constitution of the serotonin transporter promoter gene did not significantly contribute to the availability of brainstem serotonin transporters as measured by beta-CIT binding. Conclusions: In adult nonhuman primates who underwent early developmental stress, variables indicating a low serotonin turnover rate were associated with behavior patterns similar tothose predisposing to early-onset alcoholism among humans.

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Documento generato il 05/07/20 alle ore 13:28:16