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Titolo:
STUDIES ON THE PREPARATION AND IN-VITRO CYTOTOXICITY OF POLY(L-ASPARTIC ACID)DERIVATIVES-CIS-PLATIN CONJUGATES
Autore:
LU ZR; YU JH; ZHUO RX; WANG XL; YANG FH;
Indirizzi:
WUHAN UNIV,DEPT CHEM,SECC,LAB BIOMED POLYMER WUHAN 430072 PEOPLES R CHINA WUHAN UNIV,DEPT CHEM,SECC,LAB BIOMED POLYMER WUHAN 430072 PEOPLES R CHINA
Titolo Testata:
Gaodeng xuexiao huaxue xuebao
fascicolo: 5, volume: 19, anno: 1998,
pagine: 817 - 820
SICI:
0251-0790(1998)19:5<817:SOTPAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
CHI
Soggetto:
CISPLATIN;
Keywords:
POLYMER ANTITUMOR DRUG; POLYMER-CIS-PLATIN CONJUGATES; CYTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
Z.R. Lu et al., "STUDIES ON THE PREPARATION AND IN-VITRO CYTOTOXICITY OF POLY(L-ASPARTIC ACID)DERIVATIVES-CIS-PLATIN CONJUGATES", Gaodeng xuexiao huaxue xuebao, 19(5), 1998, pp. 817-820

Abstract

Three alpha,beta-poly(L-aspartic acid) derivatives-cis-platin conjugates were synthesized by conjugation of alpha,beta-poly(L-aspartic acid), (alpha,beta,L-aspartic acid)-[alpha,beta,L-(N-hydroxyethyl)aspartamide] copolymer and spartamide]-[alpha,beta,L-(N-succinyl)aspartamide] copolymer with cis-dichlorodiammine platinum( II) respectively. The polymer carriers were characterized by IR, GPC and intrinsic viscosity. The influence of pH on the conjugation reaction was studied. Cytotoxicity of polymer-cis-platin conjugates was tested against cervix uteri Hela cells in vitro, The cytotoxicity of polymer-cis-platin conjugates increases with the increase of concentration of the congugates, but lower than cis-platin of the corresponding concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:36:57