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Titolo:
DELAYED REDUCTION OF TISSUE WATER DIFFUSION AFTER MYOCARDIAL-ISCHEMIA
Autore:
HSU EW; XUE R; HOLMES A; FORDER JR;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL & RADIOL SCI,DIV NMR RES,217 TRAYLOR BLDG,720 RUTLAND AVE BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL BALTIMORE MD 21205
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 44, anno: 1998,
pagine: 697 - 702
SICI:
0363-6135(1998)44:2<697:DROTWD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE TECHNIQUES; PERFUSED RABBIT HEART; CEREBRAL-ISCHEMIA; T2-WEIGHTED MRI; ACUTE STROKE; INFARCTION; MODEL; CATS; SPECTROSCOPY; INJURY;
Keywords:
MAGNETIC RESONANCE IMAGING; APPARENT DIFFUSION COEFFICIENT; MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E.W. Hsu et al., "DELAYED REDUCTION OF TISSUE WATER DIFFUSION AFTER MYOCARDIAL-ISCHEMIA", American journal of physiology. Heart and circulatory physiology, 44(2), 1998, pp. 697-702

Abstract

The apparent diffusion coefficient (ADC) of water after regional myocardial ischemia was measured in isolated, perfused rabbit hearts by using magnetic resonance imaging (MRI) techniques. After ligation of theleft anterior descending coronary artery, the ADC of the nonperfused region showed a gradual but significant decreasing trend over time, whereas that of the normally perfused myocardium remained constant. Morphological analysis revealed that the ADC decrease reflected the expansion of a subregion of reduced ADC within the nonperfused myocardium. The dynamics of the diffusion change and the morphological progression of the affected tissue suggest that the ADC decrease may be linked to the onset of myocardial infarction, which is known to involve myocyte swelling. The ADC reduction provides a potentially valuable MRI tissue-contrast mechanism for noninvasively determining the viability of theischemic myocardium and assessing the dynamics of acute myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 06:45:23