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Titolo:
ONCOSTATIN-M REGULATES ENDOTHELIN-1 PRODUCTION IN HUMAN ENDOTHELIAL-CELLS
Autore:
SAIJONMAA O; NYMAN T; PACEK P; FYHRQUIST F;
Indirizzi:
MINERVA FDN,TUKHOLMANKATU 2 SF-00250 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,MINERVA INST MED RES SF-00250 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT INTERNAL MED SF-00250 HELSINKI FINLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 44, anno: 1998,
pagine: 662 - 667
SICI:
0363-6135(1998)44:2<662:OREPIH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA-INHIBITORY FACTOR; COLONY-STIMULATING FACTOR; VASOCONSTRICTOR PEPTIDE; EXPRESSION; GROWTH; SEQUENCE; RELEASE; FAMILY; CDNA;
Keywords:
ENDOTHELIN-1; HUMAN UMBILICAL CORD VEIN ENDOTHELIAL CELLS; INTERLEUKIN-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
O. Saijonmaa et al., "ONCOSTATIN-M REGULATES ENDOTHELIN-1 PRODUCTION IN HUMAN ENDOTHELIAL-CELLS", American journal of physiology. Heart and circulatory physiology, 44(2), 1998, pp. 662-667

Abstract

The effect of the macrophage- and T-lymphocyte-derived cytokine oncostatin M (OSM) on endothelin-1 (ET-1) production In cultured human umbilical cord vein endothelial cells (HUVEC) was studied. OSM (2.5-10 ng/ml) stimulated ET-1 production and the expression of preproendothelin-1 mRNA. The stimulatory effect of OSM was reversed by anti-interleukin(IL)-6 IgG (33 mu g/ml). IL-6 (10 ng/ml) was shown to stimulate ET-1 production. The tyrosine kinase inhibitors herbimycin (250-500 ng/ml) and genistein (1-4 mu g/ml)suppressed basal ET-1 production and reversed the stimulatory effect of OSM, whereas daidzein (1-8 mu g/ml), a less active analog of genistein, had no effect on basal ET-1 production and only partly reversed the stimulatory effect of OSM. The phorbol ester phorbol 12-myristate 13-acetate (PMA) inhibited ET-I production. Downregulation of protein kinase C (PKC) with PMA (1 mu M) preincubation potentiated OSM-induced ET-1 production. In summary, OSM stimulated ET-1 production in cultured HUVEC. The stimulation was probably mediated by IL-6. Furthermore, the present data suggest that tyrosine kinaseactivation was involved in ET-1 stimulation and that PKC activation leads to suppression of basal and OSM-stimulated ET-1 production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:33:57