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Titolo:
STRETCH-INDUCED CHANGES IN ARRHYTHMOGENESIS AND EXCITABILITY IN EXPERIMENTALLY BASED HEART CELL MODELS
Autore:
RIEMER TL; SOBIE EA; TUNG L;
Indirizzi:
JOHNS HOPKINS UNIV,DEPT BIOMED ENGN,720 RUTLAND AVE BALTIMORE MD 21205 JOHNS HOPKINS UNIV,DEPT BIOMED ENGN BALTIMORE MD 21205
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 44, anno: 1998,
pagine: 431 - 442
SICI:
0363-6135(1998)44:2<431:SCIAAE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG VENTRICULAR MYOCYTES; ACTIVATED ION CHANNELS; CARDIAC MYOCYTES; MECHANOELECTRICAL FEEDBACK; INDUCED INCREASE; EARLY AFTERDEPOLARIZATIONS; MYOCARDIAL-ISCHEMIA; MECHANICAL STRETCH; MEMBRANE CURRENTS; ARRHYTHMIAS;
Keywords:
MECHANOELECTRIC COUPLING; ELECTRICAL STIMULATION; CARDIAC MYOCYTES; STRETCH-ACTIVATED CHANNELS; MATHEMATICAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Riemer et al., "STRETCH-INDUCED CHANGES IN ARRHYTHMOGENESIS AND EXCITABILITY IN EXPERIMENTALLY BASED HEART CELL MODELS", American journal of physiology. Heart and circulatory physiology, 44(2), 1998, pp. 431-442

Abstract

Mechanoelectric coupling in the heart is well documented and has beensuggested as a cause of arrhythmia. One hypothesized mechanism for the stretch sensitivity of cardiac muscle is the presence of stretch-activated channels (SACs). This study uses modeling to explore the influence of SACs on cardiac resting potential, excitation threshold, and action potential in the context of arrhythmia. We added a putative SAG, modeled as a linear, time-independent conductance with reversal potential of -20 or -50 mV, to guinea pig and frog ventricular membrane models. Increased stretch conductance led to resting potential depolarization, a decreased excitation threshold, altered action potential duration, and, under certain conditions, early afterdepolarizations. We conclude that stretch increases cellular excitability, making the heart prone to ectopic activity. Regional effects of stretch on action potential duration can vary and are influenced by factors such as the SAC reversal potential, ionic conditions, and baseline currents, all of whichmay lead to an increased dispersion of refractoriness throughout the heart and therefore an increased risk of arrhythmia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:33:37