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Titolo:
INTERACTIONS BETWEEN ZINC AND VITAMIN-A - AN UPDATE
Autore:
CHRISTIAN P; WEST KP;
Indirizzi:
DIV HUMAN NUTR,615 N WOLFE ST,ROOM 2041 BALTIMORE MD 21205 JOHNS HOPKINS SCH PUBL HLTH,CTR HUMAN NUTR BALTIMORE MD 00000 JOHNS HOPKINS SCH PUBL HLTH,DEPT INT HLTH BALTIMORE MD 00000
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 2, volume: 68, anno: 1998, supplemento:, S
pagine: 435 - 441
SICI:
0002-9165(1998)68:2<435:IBZAV->2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOL-BINDING-PROTEIN; ABNORMAL DARK-ADAPTATION; LYMPHATIC ABSORPTION; DEFICIENT RATS; PLASMA-LEVELS; A METABOLISM; FETAL RATS; CHILDREN; SUPPLEMENTATION; GROWTH;
Keywords:
ZINC; VITAMIN A; INTERACTIONS; MECHANISMS; LIVER FUNCTION; RETINOL BINDING PROTEIN; ALCOHOL DEHYDROGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P. Christian e K.P. West, "INTERACTIONS BETWEEN ZINC AND VITAMIN-A - AN UPDATE", The American journal of clinical nutrition, 68(2), 1998, pp. 435-441

Abstract

Zinc status influences several aspects of vitamin A metabolism, including its absorption, transport, and utilization. Two common mechanismspostulated to explain this dependence relate to 1) the regulatory role of zinc in vitamin A transport mediated through protein synthesis, and 2) the oxidative conversion of retinol to retinal that requires theaction of a zinc-dependent retinol dehydrogenase enzyme. However, evidence of an effect of zinc intake on vitamin A status from animal experiments is inconclusive, mainly because of the use of inadequate control groups. The higher weight gain of control animals as compared with the zinc-deficient ones in these experiments, even though pair fed, makes it difficult to isolate effects of zinc deficiency per se from those of generalized protein-energy malnutrition. A curvilinear relation has been suggested to describe an effect of plasma zinc on vitamin A transport. In humans, cross-sectional studies have more often than not shown a weak linkage between vitamin A and zinc status. Randomized trials have failed to show a consistent effect of zinc supplementation onvitamin A status. In disease states in which liver function is severely compromised and both zinc and vitamin A metabolism and transport are impaired, serum zinc and vitamin A concentrations tend to be positively correlated. In conclusion, clear evidence of synergy between these2 micronutrients and its public health significance in humans is lacking. Research should focus on understanding this interaction in the context of coexisting moderate-to-severe zinc and vitamin A deficienciesin the population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:26:21