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Titolo:
NEW MARKERS FOR EARLY DIAGNOSIS OF ACUTE MYOCARDIAL-INFARCTION
Autore:
GALVANI M; FERRINI D; PUGGIONI R; RUGGERI S; OTTANI F;
Indirizzi:
FDN CARDIOL MYRIAM ZITO SACCO,CARDIOVASC RES UNIT,PZZA FLLI RUFFINI I-47100 FORLI ITALY DIV CARDIOL FORLI FORLI ITALY OSPED GB MORGAGNI,LAB ANAL FORLI ITALY OSPED S MARIA CROCI,DIV CARDIOL RAVENNA ITALY
Titolo Testata:
International journal of cardiology
, volume: 65, anno: 1998, supplemento:, 1
pagine: 17 - 22
SICI:
0167-5273(1998)65:<17:NMFEDO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE-MB; CARDIAC TROPONIN-I; PROGNOSTIC VALUE; UNSTABLE ANGINA; ISOENZYME MB; RAPID ASSAY; MYOGLOBIN; PLASMA; ISOFORMS; INJURY;
Keywords:
CARDIAC TROPONINS; MYOGLOBIN; CREATINE KINASE ISOFORMS; ACUTE MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Galvani et al., "NEW MARKERS FOR EARLY DIAGNOSIS OF ACUTE MYOCARDIAL-INFARCTION", International journal of cardiology, 65, 1998, pp. 17-22

Abstract

The availability of 'new' biochemical markers of myocardial injury such as creatine kinase isoforms and troponins has renewed the interest for rapid confirmation/exclusion of myocardial infarction in patients presented to the hospital for suspected acute myocardial ischemia. Many of these protein markers have the potential to allow the diagnosis of acute myocardial infarction at a time from the onset of symptoms when the activity of creatine kinase MB is still within the reference range. However, the exclusion of classical myocardial infarction as defined by WHO criteria does not allow to conclude that the patient is at low-risk and can be safely sent home since he may have high-risk unstable angina. The sensitivity for the detection of myocardial damage of troponins is such that a substantial proportion of patients with unstable angina develop elevations of troponins in the absence of creatine kinase MB increases. It is now clear that such patients have an increased risk of cardiac events over the short and long-term similar to thatof patients with definite myocardial infarction. Such finding may help in developing selective admission policies and deciding which patients deserve aggressive treatment. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:12:58