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Titolo:
NONLINEAR PHARMACOKINETICS OF FLUVOXAMINE AND GENDER DIFFERENCES
Autore:
HARTTER S; WETZEL H; HAMMES E; TORKZADEH M; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY
Titolo Testata:
Therapeutic drug monitoring
fascicolo: 4, volume: 20, anno: 1998,
pagine: 446 - 449
SICI:
0163-4356(1998)20:4<446:NPOFAG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINETICS; PLASMA; DEPRESSION; INHIBITOR; HUMANS; SINGLE;
Keywords:
SELECTIVE SEROTONIN REUPTAKE INHIBITORS; FLUVOXAMINE; PHARMACOKINETICS; GENDER DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S. Hartter et al., "NONLINEAR PHARMACOKINETICS OF FLUVOXAMINE AND GENDER DIFFERENCES", Therapeutic drug monitoring, 20(4), 1998, pp. 446-449

Abstract

This prospective study assessed fluvoxamine serum concentrations under two different fixed doses. The study included 15 male and female patients who met the DSM-III-R criteria for major depression. They were prescribed 50 mg fluvoxamine twice a day for 2 weeks and 100 mg twice aday thereafter. Drug monitoring was carried out on days 14 and 28. Fluvoxamine serum concentrations were highly variable between patients. After the dose was doubled, the serum concentrations of fluvoxamine increased disproportionately (mean, 3.4-fold), and there was a significantly (p < 0.05) more pronounced increase in men (4.6-fold) than in women (2.4-fold). These results provide evidence of nonlinear, sex-dependent pharmacokinetics of fluvoxamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:01:33