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Titolo:
TOTAL AND LIPID-BOUND SERUM SIALIC-ACID IN CHILDREN WITH MALIGNANCY OR INFECTIONS
Autore:
ROMPPANEN J; PETAJA J; HEIKINHEIMO M; MONONEN I;
Indirizzi:
KUOPIO UNIV HOSP,DEPT CLIN CHEM,POB 1777 FIN-70211 KUOPIO FINLAND KUOPIO UNIV HOSP,DEPT CLIN CHEM FIN-70211 KUOPIO FINLAND UNIV HELSINKI,CHILDRENS HOSP HELSINKI 00029 FINLAND WASHINGTON UNIV,DEPT PEDIAT,DIV PEDIAT HEMATOL ONCOL ST LOUIS MO 63110
Titolo Testata:
Anticancer research
fascicolo: 4B, volume: 18, anno: 1998,
pagine: 2793 - 2797
SICI:
0250-7005(1998)18:4B<2793:TALSSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-PATIENTS; CELLS; GLYCOSYLATION; GLYCOPROTEINS; EXPRESSION; LEUKEMIA; ENZYME; PLASMA;
Keywords:
CHILD; LASA; MALIGNANCY; SENSITIVITY; SPECIFICITY; TSA; TUMOR MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Romppanen et al., "TOTAL AND LIPID-BOUND SERUM SIALIC-ACID IN CHILDREN WITH MALIGNANCY OR INFECTIONS", Anticancer research, 18(4B), 1998, pp. 2793-2797

Abstract

Increased levels of sialic acid-containing glycoconjugates in serum have been observed in malignancies. In this study, significantly elevated serum concentrations of total sialic acid (TSA), TSA/total protein (TSA/TP) and lipid-bound sialic acid (LASA) were observed at diagnosisof children with various malignancies compared to healthy children. Serum TSA and TSA/TP were superior to LASA in differentiating solid tumors (p<0.005) and leukemias (p<0.05) from normal controls. In neuroblastoma and yolk snc tumors, a descending trend in TSA and TSA/TP was noted after successful treatment of the malignancy. Children with simultaneous malignancy and infection had significantly higher serum TSA (p<0.05) and TSA/TP (p<0.01) levels compared to patients with infections diseases only, the corresponding areas under the curve were 0.83 and 0.88. The measurement of serum TSA and TSA/TP could be useful adjuncts in exclusion, diagnosis and follow-up of malignancies in children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:20:44