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Titolo:
NEUROCHEMICAL DISTINCTION BETWEEN SKELETAL-MUSCLE VASODILATOR NEURONSAND PELVIC VASODILATOR NEURONS IN GUINEA-PIGS
Autore:
MORRIS JL; GRASBY DJ; ANDERSON RL; GIBBINS IL;
Indirizzi:
FLINDERS UNIV S AUSTRALIA,CTR NEUROSCI,GPO BOX 2100 ADELAIDE SA 5001 AUSTRALIA FLINDERS UNIV S AUSTRALIA,DEPT ANAT & HISTOL ADELAIDE SA 5001 AUSTRALIA
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1, volume: 71, anno: 1998,
pagine: 64 - 68
SICI:
0165-1838(1998)71:1<64:NDBSVN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SYMPATHETIC-GANGLIA; SENSORY NEURONS; CO-EXISTENCE; SUBSTANCE-P; PEPTIDES; NERVES; STIMULATION; DYNORPHIN;
Keywords:
VASODILATOR NEURONS; SYMPATHETIC NEURONS; PELVIC NEURONS; NEUROCHEMICAL MARKERS; COLOCALIZATION; VASOACTIVE INTESTINAL PEPTIDE (VIP); NITRIC OXIDE SYNTHASE (NOS); CALCITONIN GENE-RELATED PEPTIDE (CGRP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Morris et al., "NEUROCHEMICAL DISTINCTION BETWEEN SKELETAL-MUSCLE VASODILATOR NEURONSAND PELVIC VASODILATOR NEURONS IN GUINEA-PIGS", Journal of the autonomic nervous system, 71(1), 1998, pp. 64-68

Abstract

This study sets out to compare the combinations of potential vasodilator transmitters expressed by sympathetic and pelvic vasodilator neurons of guinea-pigs. Triple-labelling fluorescence immunohistochemistry was used to examine immunoreactivity (IR) to vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) in lumbar sympathetic ganglia, and in perivascular axons supplying hindlimb skeletal muscles or pelvic viscera. Only 0.2% of VIP-IR nerve cell bodies in lumbar sympathetic ganglia (n = 4632 VIP-IR nerve cell profiles) contained NOS-IR, and one VIP-IR neuron containedCGRP-IR. The VIP-TR perivascular axons along the common and external iliac arteries, femoral artery and arteries to hindlimb muscles lackedNOS-IR and CGRP-IR. In contrast, all VIP-IR perivascular axons projecting from pelvic ganglia to the main uterine artery, and half of the VIP-IR axons along the internal iliac artery, contained NOS-IR and CGRP-IR. Thus, the neurochemical content of sympathetic vasodilator neurons to skeletal muscle arteries was clearly distinguishable from that ofpelvic vasodilator neurons to the uterine vasculature. Furthermore, the autonomic dilation in each vascular bed is likely to be qualitatively different, and matched to the functional requirements of each target organ. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:19:05