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Titolo:
AMPA RECEPTOR DESENSITIZATION MODULATES SYNAPTIC RESPONSES INDUCED BYREPETITIVE AFFERENT STIMULATION IN HIPPOCAMPAL SLICES
Autore:
AMY A; LYNCH G;
Indirizzi:
UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92697 UNIV CALIF IRVINE,DEPT PSYCHIAT IRVINE CA 92697
Titolo Testata:
Brain research
fascicolo: 2, volume: 799, anno: 1998,
pagine: 235 - 242
SICI:
0006-8993(1998)799:2<235:ARDMSR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-OPERATED CHANNELS; LONG-TERM POTENTIATION; TIME-COURSE; KAINATE RECEPTORS; RAT HIPPOCAMPUS; PATCHES; TRANSMISSION; KINETICS; SYNAPSES; NEURONS;
Keywords:
CYCLOTHIAZIDE; EXCISED PATCH; CA1; PYRAMIDAL NEURON; THETA BURST; LONG-TERM POTENTIATION, LTP; SYNAPTIC PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Amy e G. Lynch, "AMPA RECEPTOR DESENSITIZATION MODULATES SYNAPTIC RESPONSES INDUCED BYREPETITIVE AFFERENT STIMULATION IN HIPPOCAMPAL SLICES", Brain research, 799(2), 1998, pp. 235-242

Abstract

In patches excised from CA1 pyramidal cells, peak amplitudes of currents evoked by brief glutamate pulses grew progressively smaller over aseries of high-frequency pulses. This decline was eliminated by cyclothiazide, a drug previously shown to block AMPA receptor desensitization. In hippocampal slices, synaptically evoked bursts exhibited an increase from the first to the second response, presumably due to facilitation of transmitter release, but the subsequent responses gradually declined in amplitude. Cyclothiazide attenuated or reversed this decline; after normalization to the first response, the amplitudes of the later responses to a 50 Hz series of afferent stimulation were increasedby 20-25% in regular recording medium and by as much as 40% when transmitter release was enhanced in a high-calcium medium. The effect of cyclothiazide was greatly diminished when the stimulation frequency wasreduced to 33 or 25 Hz. Comparable results were obtained in slices inwhich NMDA, GABA(A), and GABA(B) receptors were blocked. The ampakinedrug CX516 which has only a minor influence on desensitization kinetics did not differentially facilitate the later responses to high-frequency afferent stimulation. These results suggest that the desensitization of AMPA receptors contributes importantly to synaptic activity when afferents are repetitively activated at high-frequency. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:12:07