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Titolo:
THE WAVE-FORM OF SYNAPTIC TRANSMISSION AT HIPPOCAMPAL SYNAPSES IS NOTDETERMINED BY AMPA RECEPTOR DESENSITIZATION
Autore:
ARAI A; LYNCH G;
Indirizzi:
UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92697 UNIV CALIF IRVINE,DEPT PSYCHIAT IRVINE CA 92697
Titolo Testata:
Brain research
fascicolo: 2, volume: 799, anno: 1998,
pagine: 230 - 234
SICI:
0006-8993(1998)799:2<230:TWOSTA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINATE RECEPTORS; GLUTAMATE; CURRENTS; NEURONS; SLICES; DRUG; CYCLOTHIAZIDE; PATCHES; POTENTIATION; ANIRACETAM;
Keywords:
AMPA RECEPTOR DESENSITIZATION; DEACTIVATION; CYCLOTHIAZIDE; AMPAKINE; EPSP; BENZAMIDE; BENZOYLPIPERIDINE; BENZOTHIADIAZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Arai e G. Lynch, "THE WAVE-FORM OF SYNAPTIC TRANSMISSION AT HIPPOCAMPAL SYNAPSES IS NOTDETERMINED BY AMPA RECEPTOR DESENSITIZATION", Brain research, 799(2), 1998, pp. 230-234

Abstract

Relationships between the kinetic properties of AMPA receptors and the decay phase of fast excitatory transmission were investigated using modulatory drugs. The benzothiadiazide compound cyclothiazide blocked receptor desensitization in patches excised from hippocampus but had only a weak influence on receptor deactivation, i.e., on the decay of responses produced by a 1-ms pulse of glutamate. The ampakine drug CX516 (BDP-12) produced an opposite pattern of effects: a fourfold slowingof deactivation with little change in desensitization. A structurallyrelated drug (CX554 or BDP-20) had prominent effects on both desensitization and deactivation. The halfwidth of field EPSPs measured in theCA1 region of hippocampal slices increased 50-100% in the presence ofCX516 or CX554 but by less than 15% at concentrations of cyclothiazide that fully blocked desensitization in patch experiments. These results indicate that receptor deactivation plays a substantially greater role than receptor desensitization in determining the duration of synaptic responses. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 13:05:29