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Titolo:
AMPA RECEPTOR PROPERTIES IN ADULT-RAT HIPPOCAMPUS FOLLOWING ENVIRONMENTAL ENRICHMENT
Autore:
GAGNE J; GELINAS S; MARTINOLI MG; FOSTER TC; OHAYON M; THOMPSON RF; BAUDRY M; MASSICOTTE G;
Indirizzi:
UNIV QUEBEC,DEPT CHIM BIOL,CP 500 TROIS RIVIERES PQ G9A 5H7 CANADA UNIV QUEBEC,DEPT CHIM BIOL TROIS RIVIERES PQ G9A 5H7 CANADA UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089 CTR RECH PHILIPPE PINEL MONTREAL PQ H1C 1H1 CANADA UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Brain research
fascicolo: 1, volume: 799, anno: 1998,
pagine: 16 - 25
SICI:
0006-8993(1998)799:1<16:ARPIAH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; MEMBRANE PHOSPHOLIPID ASYMMETRY; PHOSPHATIDYLSERINE INCREASES; QUISQUALATE RECEPTORS; GLUTAMATE RECEPTORS; BLOOD-PLATELETS; RED-CELLS; AREA CA1; BRAIN; ACTIVATION;
Keywords:
GLUTAMATE RECEPTORS; MODULATION; EXPRESSION; ENVIRONMENTAL ENRICHMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Gagne et al., "AMPA RECEPTOR PROPERTIES IN ADULT-RAT HIPPOCAMPUS FOLLOWING ENVIRONMENTAL ENRICHMENT", Brain research, 799(1), 1998, pp. 16-25

Abstract

In adult rats, environmental enrichment has been shown to selectivelyincrease H-3-AMPA binding in the hippocampus but the molecular mechanisms underlying this effect remain unknown. We used in situ hybridization with antisense oligonucleotides to determine possible changes in the hippocampal expression of messenger RNAs for different subunits of AMPA receptors in adult rats following exposure to an enriched environment. Quantitative analysis revealed that mRNA levels for three subtypes of AMPA glutamate receptors (GluR1-3; Flip and Flop variants) were not modified in any hippocampal region after environmental enrichment. In addition, no differences were detected in the levels of GluR1 and GluR2/3 proteins in Western blots of hippocampal membranes from enriched rats. Nevertheless, quantitative ligand binding autoradiography indicated that environmental enrichment evoked a significant and uniform decrease in the capacity of calcium or phosphatidylserine (PS) to up-regulate H-3-AMPA binding in various hippocampal regions but not in thecerebral cortex. These findings support previous observations suggesting that post-translational changes in AMPA receptor properties, as a result of the activation of calcium-dependent processes, may representan important mechanism underlying long-term modifications of synapticefficacy in the rat hippocampus. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:21:08