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Titolo:
ASSOCIATION OF INHALED CORTICOSTEROID USE WITH CATARACT-EXTRACTION INELDERLY PATIENTS
Autore:
GARBE E; SUISSA S; LELORIER J;
Indirizzi:
POTSDAM INST PHARMACOEPIDEMIOL & TECHNOL ASSESSME,OTTO ERICH STR 7 D-14482 POTSDAM GERMANY ROYAL VICTORIA HOSP,DIV CLIN EPIDEMIOL MONTREAL PQ H3A 1A1 CANADA MCGILL UNIV,DEPT EPIDEMIOL & BIOSTAT MONTREAL PQ CANADA UNIV MONTREAL,HOTEL DIEU,CTR RECH MONTREAL PQ CANADA
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 6, volume: 280, anno: 1998,
pagine: 539 - 543
SICI:
0098-7484(1998)280:6<539:AOICUW>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR SUBCAPSULAR CATARACTS; ASPIRIN-LIKE ANALGESICS; AGE-RELATED CATARACTS; RISK-FACTORS; STEROID AEROSOLS; ASTHMA; THERAPY; BECLOMETHASONE; GLUCOCORTICOIDS; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
E. Garbe et al., "ASSOCIATION OF INHALED CORTICOSTEROID USE WITH CATARACT-EXTRACTION INELDERLY PATIENTS", JAMA, the journal of the American Medical Association, 280(6), 1998, pp. 539-543

Abstract

Context.-The use of systemic corticosteroids is a known risk factor for the development of cataracts. Objective.-To determine whether treatment with inhaled corticosteroids is associated with cataract extraction in the elderly. Design.-Case-control study. Setting.-Quebec universal health insurance program for all elderly (provincial health insurance plan database [RAMQ database]). Patients.-RAMQ enrollees 70 years and older. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21 868 controls were randomly selected from patients who did not have a diagnosis of cataract and matched to cases onthe index date of the case. Main Outcome Measures.-Odds ratio of cataract extraction in patients with prolonged cumulative exposure to inhaled corticosteroids compared with nonusers. Results.-Excluding patients with systemic steroid treatment and after adjusting for age, sex, diabetes, systemic hypertension, glaucoma, ophthalmic steroids, and the number of physician claims for services, use of inhaled corticosteroids for more than 3 years was associated with undergoing cataract extraction (odds ratio [OR], 3.06; 95% confidence interval [CI], 1.53-6.13). For high average daily doses of beclomethasone or budesonide (>1 mg),the OR was elevated after more than 2 years of treatment (OR, 3.40; 95% CI, 1.49-7.76), whereas for low to medium doses (less than or equalto 1 mg) of these drugs, the OR was 1.63 (95% CI, 0.85-3.13) after 2 years. Conclusion.-Prolonged administration of high doses of inhaled corticosteroids increases the likelihood of undergoing cataract extraction in elderly patients. Further studies are needed to investigate therisk of developing cataracts for low to medium doses over longer periods.

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Documento generato il 22/09/20 alle ore 14:28:41